The transcription factor HNF-4α: a key player in haematological disorders

HNF-4α is a member of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, apolipoproteins and blood coagulation. The transcriptional potency of HNF-4α i...

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Autores principales: Belali, Tareg, Abomughaid, Mosleh, Alhujaily, Muhanad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
State of the Art Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696958/
http://dx.doi.org/10.5114/aoms/141219
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author Belali, Tareg
Abomughaid, Mosleh
Alhujaily, Muhanad
author_facet Belali, Tareg
Abomughaid, Mosleh
Alhujaily, Muhanad
author_sort Belali, Tareg
collection PubMed
description HNF-4α is a member of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, apolipoproteins and blood coagulation. The transcriptional potency of HNF-4α is well known due to its involvement in diabetes and other metabolic diseases. However, recently HNF-4α has been discovered to be closely associated with several haematological disorders, mainly because of genetic mutations, drugs, and hepatic disorders. We review HNF-4α structure and function, and its role in haematological disorders. We discuss possible novel therapies that are based on targeting HNF-4α.
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spelling pubmed-106969582023-12-06 The transcription factor HNF-4α: a key player in haematological disorders Belali, Tareg Abomughaid, Mosleh Alhujaily, Muhanad Arch Med Sci State of the Art Paper HNF-4α is a member of the steroid hormone receptor family of transcription factors with roles in the development of the liver and the regulation of several critical metabolic pathways, such as glycolysis, drug metabolism, apolipoproteins and blood coagulation. The transcriptional potency of HNF-4α is well known due to its involvement in diabetes and other metabolic diseases. However, recently HNF-4α has been discovered to be closely associated with several haematological disorders, mainly because of genetic mutations, drugs, and hepatic disorders. We review HNF-4α structure and function, and its role in haematological disorders. We discuss possible novel therapies that are based on targeting HNF-4α. Termedia Publishing House 2021-08-13 /pmc/articles/PMC10696958/ http://dx.doi.org/10.5114/aoms/141219 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle State of the Art Paper
Belali, Tareg
Abomughaid, Mosleh
Alhujaily, Muhanad
The transcription factor HNF-4α: a key player in haematological disorders
title The transcription factor HNF-4α: a key player in haematological disorders
title_full The transcription factor HNF-4α: a key player in haematological disorders
title_fullStr The transcription factor HNF-4α: a key player in haematological disorders
title_full_unstemmed The transcription factor HNF-4α: a key player in haematological disorders
title_short The transcription factor HNF-4α: a key player in haematological disorders
title_sort transcription factor hnf-4α: a key player in haematological disorders
topic State of the Art Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696958/
http://dx.doi.org/10.5114/aoms/141219
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