Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas

Approximately half of patients with cancer receive radiotherapy and, as cancer survivorship increases, the low rate of radiation-associated sarcomas is rising. Pharmacologic inhibition of p53 has been proposed as an approach to ameliorate acute injury of normal tissues from genotoxic therapies, but...

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Detalles Bibliográficos
Autores principales: Daniel, Andrea R., Su, Chang, Williams, Nerissa T., Li, Zhiguo, Huang, Jianguo, Lopez, Omar, Luo, Lixia, Ma, Yan, Campos, Lorraine da Silva, Selitsky, Sara R., Modliszewski, Jennifer L., Liu, Siyao, Hernansaiz-Ballesteros, Rosa, Mowery, Yvonne M., Cardona, Diana M., Lee, Chang-Lung, Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697056/
https://www.ncbi.nlm.nih.gov/pubmed/37982576
http://dx.doi.org/10.1158/2767-9764.CRC-23-0104

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