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Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

The interleukin-4 (IL-4) cytokine plays a critical role in modulating immune homeostasis. Although there is great interest in harnessing this cytokine as a therapeutic in natural or engineered formats, the clinical potential of native IL-4 is limited by its instability and pleiotropic actions. Here,...

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Detalles Bibliográficos
Autores principales:	Yang, Huilin, Ulge, Umut Y., Quijano-Rubio, Alfredo, Bernstein, Zachary J., Maestas, David R., Chun, Jung-Ho, Wang, Wentao, Lin, Jian-Xin, Jude, Kevin M., Singh, Srujan, Orcutt-Jahns, Brian T., Li, Peng, Mou, Jody, Chung, Liam, Kuo, Yun-Huai, Ali, Yasmin H., Meyer, Aaron S., Grayson, Warren L., Heller, Nicola M., Christopher Garcia, K., Leonard, Warren J., Silva, Daniel-Adriano, Elisseeff, Jennifer H., Baker, David, Spangler, Jamie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697138/ https://www.ncbi.nlm.nih.gov/pubmed/37024727 http://dx.doi.org/10.1038/s41589-023-01313-6

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