Cargando…

Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)

Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Taneri, Petek Eylul, Kirkham, Jamie J., Molloy, Eleanor J., Biesty, Linda, Polin, Richard A., Wynn, James L., Stoll, Barbara J., Kissoon, Niranjan, Kawaza, Kondwani, Daly, Mandy, Branagan, Aoife, Bonnard, Lívia Nagy, Giannoni, Eric, Strunk, Tobias, Ohaja, Magdalena, Mugabe, Kenneth, Suguitani, Denise, Quirke, Fiona, Devane, Declan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697588/
http://dx.doi.org/10.1371/journal.pone.0295325
_version_ 1785154780913467392
author Taneri, Petek Eylul
Kirkham, Jamie J.
Molloy, Eleanor J.
Biesty, Linda
Polin, Richard A.
Wynn, James L.
Stoll, Barbara J.
Kissoon, Niranjan
Kawaza, Kondwani
Daly, Mandy
Branagan, Aoife
Bonnard, Lívia Nagy
Giannoni, Eric
Strunk, Tobias
Ohaja, Magdalena
Mugabe, Kenneth
Suguitani, Denise
Quirke, Fiona
Devane, Declan
author_facet Taneri, Petek Eylul
Kirkham, Jamie J.
Molloy, Eleanor J.
Biesty, Linda
Polin, Richard A.
Wynn, James L.
Stoll, Barbara J.
Kissoon, Niranjan
Kawaza, Kondwani
Daly, Mandy
Branagan, Aoife
Bonnard, Lívia Nagy
Giannoni, Eric
Strunk, Tobias
Ohaja, Magdalena
Mugabe, Kenneth
Suguitani, Denise
Quirke, Fiona
Devane, Declan
author_sort Taneri, Petek Eylul
collection PubMed
description Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients’ parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
format Online
Article
Text
id pubmed-10697588
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-106975882023-12-06 Protocol for the development of a core outcome set for neonatal sepsis (NESCOS) Taneri, Petek Eylul Kirkham, Jamie J. Molloy, Eleanor J. Biesty, Linda Polin, Richard A. Wynn, James L. Stoll, Barbara J. Kissoon, Niranjan Kawaza, Kondwani Daly, Mandy Branagan, Aoife Bonnard, Lívia Nagy Giannoni, Eric Strunk, Tobias Ohaja, Magdalena Mugabe, Kenneth Suguitani, Denise Quirke, Fiona Devane, Declan PLoS One Study Protocol Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients’ parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste. Public Library of Science 2023-12-05 /pmc/articles/PMC10697588/ http://dx.doi.org/10.1371/journal.pone.0295325 Text en © 2023 Taneri et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Taneri, Petek Eylul
Kirkham, Jamie J.
Molloy, Eleanor J.
Biesty, Linda
Polin, Richard A.
Wynn, James L.
Stoll, Barbara J.
Kissoon, Niranjan
Kawaza, Kondwani
Daly, Mandy
Branagan, Aoife
Bonnard, Lívia Nagy
Giannoni, Eric
Strunk, Tobias
Ohaja, Magdalena
Mugabe, Kenneth
Suguitani, Denise
Quirke, Fiona
Devane, Declan
Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title_full Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title_fullStr Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title_full_unstemmed Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title_short Protocol for the development of a core outcome set for neonatal sepsis (NESCOS)
title_sort protocol for the development of a core outcome set for neonatal sepsis (nescos)
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697588/
http://dx.doi.org/10.1371/journal.pone.0295325
work_keys_str_mv AT taneripetekeylul protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT kirkhamjamiej protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT molloyeleanorj protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT biestylinda protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT polinricharda protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT wynnjamesl protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT stollbarbaraj protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT kissoonniranjan protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT kawazakondwani protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT dalymandy protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT branaganaoife protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT bonnardlivianagy protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT giannonieric protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT strunktobias protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT ohajamagdalena protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT mugabekenneth protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT suguitanidenise protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT quirkefiona protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos
AT devanedeclan protocolforthedevelopmentofacoreoutcomesetforneonatalsepsisnescos