Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

Macrophages play a pivotal role in tumor immunity. We report that reprogramming of macrophages to tumor-associated macrophages (TAMs) promotes the secretion of exosomes. Mechanistically, increased exosome secretion is driven by MADD, which is phosphorylated by Akt upon TAM induction and activates Ra...

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Detalles Bibliográficos
Autores principales: Zhong, Wenqun, Lu, Youtao, Han, Xuexiang, Yang, Jingbo, Qin, Zhiyuan, Zhang, Wei, Yu, Ziyan, Wu, Bin, Liu, Shujing, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Karakousis, Giorgos C., Mitchell, Tara C., Amaravadi, Ravi, Flowers, Ahron J., Gimotty, Phyllis A., Xiao, Min, Gordon, Mills, Meenhard, Herlyn, Haidong, Dong, Mitchell, Michael J., Kim, Junhyong, Xu, Xiaowei, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10697782/
https://www.ncbi.nlm.nih.gov/pubmed/37805922
http://dx.doi.org/10.1016/j.celrep.2023.113224

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