HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector

BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these s...

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Detalles Bibliográficos
Autores principales: Anderson, Joseph, Akkina, Ramesh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074340/
https://www.ncbi.nlm.nih.gov/pubmed/15813990
http://dx.doi.org/10.1186/1742-6405-2-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074340/
https://www.ncbi.nlm.nih.gov/pubmed/15813990
http://dx.doi.org/10.1186/1742-6405-2-1

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