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Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tolerance after repeated opioid administration. Glutamate receptors have been reported to criti...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074357/ https://www.ncbi.nlm.nih.gov/pubmed/15813995 http://dx.doi.org/10.1186/1744-8069-1-7 |