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Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus
Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions...
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074709/ https://www.ncbi.nlm.nih.gov/pubmed/15912193 |
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author | Pimenta, Flávio Juliano Garcia Santos Pinheiro, Maria das Graças Rodrigues Gomez, Ricardo Santiago |
author_facet | Pimenta, Flávio Juliano Garcia Santos Pinheiro, Maria das Graças Rodrigues Gomez, Ricardo Santiago |
author_sort | Pimenta, Flávio Juliano Garcia Santos |
collection | PubMed |
description | Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair (hMMR) genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular (46.54%; p=0,006) and atrophic/erosive (48.79%; p=0,028) subtypes of oral lichen planus compared to normal mucosa (61.29%). The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma. |
format | Text |
id | pubmed-1074709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-10747092005-05-18 Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus Pimenta, Flávio Juliano Garcia Santos Pinheiro, Maria das Graças Rodrigues Gomez, Ricardo Santiago Int J Med Sci Research Paper Lichen planus is a mucocutaneous disease of inflammatory nature and unknown etiology. It is characterized by a cell-mediated immunological response to induced antigenic change in skin and/or mucosa. The possible malignant transformation of lichen planus remains a subject of controversial discussions in the literature. hMSH2 is one of the human DNA mismatch repair (hMMR) genes and it plays an important role in reducing mutation and maintaining genomic stability. hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma. In this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium. We examined the expression of hMSH2 protein by immunohistochemistry in twenty-six cases of oral lichen planus. Clinically, 12 of them were categorized into reticular subtype and 14 were atrophic/erosive. Ten cases of normal mucosa were added to the control group. Results showed that the percentage of positive cells to hMSH2 was smaller in reticular (46.54%; p=0,006) and atrophic/erosive (48.79%; p=0,028) subtypes of oral lichen planus compared to normal mucosa (61.29%). The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma. Ivyspring International Publisher 2004-08-05 /pmc/articles/PMC1074709/ /pubmed/15912193 Text en © Ivyspring International Publisher. This is an open access article. Distribution or copying is permitted, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Pimenta, Flávio Juliano Garcia Santos Pinheiro, Maria das Graças Rodrigues Gomez, Ricardo Santiago Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title | Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title_full | Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title_fullStr | Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title_full_unstemmed | Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title_short | Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus |
title_sort | expression of hmsh2 protein of the human dna mismatch repair system in oral lichen planus |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074709/ https://www.ncbi.nlm.nih.gov/pubmed/15912193 |
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