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Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women

BACKGROUND: Adverse drug reactions (ADR's) could be expected more frequently in pregnant women. This study was performed in order to identify ADR's to tocolytic drugs in hospitalised pregnant women. METHODS: A prospective cohort study was performed in two General Hospitals of the Instituto...

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Autores principales: Hernández-Hernández, Dulce María, Vargas-Rivera, María Josefa E, Nava-Ocampo, Alejandro A, Palma-Aguirre, José Antonio, Sumano-López, Héctor
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC107840/
https://www.ncbi.nlm.nih.gov/pubmed/11934352
http://dx.doi.org/10.1186/1471-2393-2-3
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author Hernández-Hernández, Dulce María
Vargas-Rivera, María Josefa E
Nava-Ocampo, Alejandro A
Palma-Aguirre, José Antonio
Sumano-López, Héctor
author_facet Hernández-Hernández, Dulce María
Vargas-Rivera, María Josefa E
Nava-Ocampo, Alejandro A
Palma-Aguirre, José Antonio
Sumano-López, Héctor
author_sort Hernández-Hernández, Dulce María
collection PubMed
description BACKGROUND: Adverse drug reactions (ADR's) could be expected more frequently in pregnant women. This study was performed in order to identify ADR's to tocolytic drugs in hospitalised pregnant women. METHODS: A prospective cohort study was performed in two General Hospitals of the Instituto Mexicano del Seguro Social (IMSS) in Mexico City. Two hundred and seven women undergoing labor, premature labor, threatened abortion or suffering any obstetric related disease were included. Drug prescription and signs and symptoms of any potential ADR were registered daily during the hospital stay. Any potential ADR to tocolytic drugs was evaluated and classified by three of the authors using the Kramer's algorithm. RESULTS: Of the 207 patients, an ADR was positively classified in 25 cases (12.1%, CI95% 8.1 to 17.5%). All ADR's were classified as minor reactions. Grouping patients with diagnosis of threatened abortion, premature labor or under labor (n= 114), 24 ADR's were related to terbutaline, accounting for a rate of 21.1 ADR's per 100 obstetric patients. Obstetric patients suffering an ADR were older than obstetric patients without any ADR. However, the former received less drugs/day × patient(-1) and had a shorter hospital stay (p < 0.05) whereas the dose of terbutaline was similar between the two groups. Terbutaline inhibited uterine motility in women with and without any ADR at a similar rate, 70 and 76% respectively (x(2) = 0.07; p = 0.8). CONCLUSION: Terbutaline, used as a tocolytic drug, was related to a high frequency of minor ADRs and to a high rate of effcicacy.
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spelling pubmed-1078402002-05-09 Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women Hernández-Hernández, Dulce María Vargas-Rivera, María Josefa E Nava-Ocampo, Alejandro A Palma-Aguirre, José Antonio Sumano-López, Héctor BMC Pregnancy Childbirth Research Article BACKGROUND: Adverse drug reactions (ADR's) could be expected more frequently in pregnant women. This study was performed in order to identify ADR's to tocolytic drugs in hospitalised pregnant women. METHODS: A prospective cohort study was performed in two General Hospitals of the Instituto Mexicano del Seguro Social (IMSS) in Mexico City. Two hundred and seven women undergoing labor, premature labor, threatened abortion or suffering any obstetric related disease were included. Drug prescription and signs and symptoms of any potential ADR were registered daily during the hospital stay. Any potential ADR to tocolytic drugs was evaluated and classified by three of the authors using the Kramer's algorithm. RESULTS: Of the 207 patients, an ADR was positively classified in 25 cases (12.1%, CI95% 8.1 to 17.5%). All ADR's were classified as minor reactions. Grouping patients with diagnosis of threatened abortion, premature labor or under labor (n= 114), 24 ADR's were related to terbutaline, accounting for a rate of 21.1 ADR's per 100 obstetric patients. Obstetric patients suffering an ADR were older than obstetric patients without any ADR. However, the former received less drugs/day × patient(-1) and had a shorter hospital stay (p < 0.05) whereas the dose of terbutaline was similar between the two groups. Terbutaline inhibited uterine motility in women with and without any ADR at a similar rate, 70 and 76% respectively (x(2) = 0.07; p = 0.8). CONCLUSION: Terbutaline, used as a tocolytic drug, was related to a high frequency of minor ADRs and to a high rate of effcicacy. BioMed Central 2002-04-05 /pmc/articles/PMC107840/ /pubmed/11934352 http://dx.doi.org/10.1186/1471-2393-2-3 Text en Copyright © 2002 Hernández-Hernández et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Hernández-Hernández, Dulce María
Vargas-Rivera, María Josefa E
Nava-Ocampo, Alejandro A
Palma-Aguirre, José Antonio
Sumano-López, Héctor
Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title_full Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title_fullStr Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title_full_unstemmed Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title_short Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
title_sort drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC107840/
https://www.ncbi.nlm.nih.gov/pubmed/11934352
http://dx.doi.org/10.1186/1471-2393-2-3
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