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Two cases of "cannabis acute psychosis" following the administration of oral cannabis

BACKGROUND: Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. CASE PRESENTATIONS: We report two cases of healthy subjects who...

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Autores principales: Favrat, Bernard, Ménétrey, Annick, Augsburger, Marc, Rothuizen, Laura E, Appenzeller, Monique, Buclin, Thierry, Pin, Marie, Mangin, Patrice, Giroud, Christian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079888/
https://www.ncbi.nlm.nih.gov/pubmed/15804348
http://dx.doi.org/10.1186/1471-244X-5-17
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author Favrat, Bernard
Ménétrey, Annick
Augsburger, Marc
Rothuizen, Laura E
Appenzeller, Monique
Buclin, Thierry
Pin, Marie
Mangin, Patrice
Giroud, Christian
author_facet Favrat, Bernard
Ménétrey, Annick
Augsburger, Marc
Rothuizen, Laura E
Appenzeller, Monique
Buclin, Thierry
Pin, Marie
Mangin, Patrice
Giroud, Christian
author_sort Favrat, Bernard
collection PubMed
description BACKGROUND: Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. CASE PRESENTATIONS: We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. CONCLUSION: While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur.
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spelling pubmed-10798882005-04-15 Two cases of "cannabis acute psychosis" following the administration of oral cannabis Favrat, Bernard Ménétrey, Annick Augsburger, Marc Rothuizen, Laura E Appenzeller, Monique Buclin, Thierry Pin, Marie Mangin, Patrice Giroud, Christian BMC Psychiatry Case Report BACKGROUND: Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. CASE PRESENTATIONS: We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. CONCLUSION: While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur. BioMed Central 2005-04-01 /pmc/articles/PMC1079888/ /pubmed/15804348 http://dx.doi.org/10.1186/1471-244X-5-17 Text en Copyright © 2005 Favrat et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Favrat, Bernard
Ménétrey, Annick
Augsburger, Marc
Rothuizen, Laura E
Appenzeller, Monique
Buclin, Thierry
Pin, Marie
Mangin, Patrice
Giroud, Christian
Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title_full Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title_fullStr Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title_full_unstemmed Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title_short Two cases of "cannabis acute psychosis" following the administration of oral cannabis
title_sort two cases of "cannabis acute psychosis" following the administration of oral cannabis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079888/
https://www.ncbi.nlm.nih.gov/pubmed/15804348
http://dx.doi.org/10.1186/1471-244X-5-17
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