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Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital

BACKGROUND: The purpose of this study was to retrospectively evaluate our experience with gallbladder cancer since the establishment of a tumour registry in our institute. METHODS: Between 1975 and 1998, 23 consecutive patients with gallbladder cancer were identified using the tumour registry databa...

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Autores principales: Memon, Muhammed Ashraf, Anwar, Suhail, Shiwani, M Hanif, Memon, Breda
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079924/
https://www.ncbi.nlm.nih.gov/pubmed/15774016
http://dx.doi.org/10.1186/1477-7800-2-6
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author Memon, Muhammed Ashraf
Anwar, Suhail
Shiwani, M Hanif
Memon, Breda
author_facet Memon, Muhammed Ashraf
Anwar, Suhail
Shiwani, M Hanif
Memon, Breda
author_sort Memon, Muhammed Ashraf
collection PubMed
description BACKGROUND: The purpose of this study was to retrospectively evaluate our experience with gallbladder cancer since the establishment of a tumour registry in our institute. METHODS: Between 1975 and 1998, 23 consecutive patients with gallbladder cancer were identified using the tumour registry database. There were 18 females (78%) and 5 (22%) males. The mean age at diagnosis was 70.6 (range 42–85) years. The diagnosis was achieved either intra-operatively or following the histological analysis of the gallbladder (n = 17), following gallbladder or liver biopsy (n = 4) or at autopsy (n = 2). Presenting symptoms included upper abdominal pain, weight loss, nausea, vomiting, fever, painless jaundice, hepatomegaly, upper abdominal mass, upper abdominal tenderness, and gastrointestinal haemorrhage. RESULTS: Histological examination revealed 20 adenocarcinomas (87%), 2 squamous cell carcinomas (9%) and one spindle cell sarcoma (4%). At presentation, 14 (61%) gallbladder cancers were stage IV, 5 (22%) were stage III and 4 (17%) were stage II. Kaplan Meier analysis revealed a mean survival of 3.2, 7.8 and 8.2 months for stage IV, III, and II disease respectively. Out of 14 patients with stage IV disease, 8 patients received adjuvant chemotherapy and survived for 4.6 months whereas six patients who did not receive adjuvant chemotherapy survived for 1.3 months. This difference was statistically significant (p = 0.04). CONCLUSION: The majority of patients with gallbladder cancer presented with advanced stage disease (stage IV) which carries a dismal prognosis. Patients who received chemotherapy with stage IV disease, however, did better than those who did not, but this is probably a reflection of patient selection.
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spelling pubmed-10799242005-04-15 Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital Memon, Muhammed Ashraf Anwar, Suhail Shiwani, M Hanif Memon, Breda Int Semin Surg Oncol Research BACKGROUND: The purpose of this study was to retrospectively evaluate our experience with gallbladder cancer since the establishment of a tumour registry in our institute. METHODS: Between 1975 and 1998, 23 consecutive patients with gallbladder cancer were identified using the tumour registry database. There were 18 females (78%) and 5 (22%) males. The mean age at diagnosis was 70.6 (range 42–85) years. The diagnosis was achieved either intra-operatively or following the histological analysis of the gallbladder (n = 17), following gallbladder or liver biopsy (n = 4) or at autopsy (n = 2). Presenting symptoms included upper abdominal pain, weight loss, nausea, vomiting, fever, painless jaundice, hepatomegaly, upper abdominal mass, upper abdominal tenderness, and gastrointestinal haemorrhage. RESULTS: Histological examination revealed 20 adenocarcinomas (87%), 2 squamous cell carcinomas (9%) and one spindle cell sarcoma (4%). At presentation, 14 (61%) gallbladder cancers were stage IV, 5 (22%) were stage III and 4 (17%) were stage II. Kaplan Meier analysis revealed a mean survival of 3.2, 7.8 and 8.2 months for stage IV, III, and II disease respectively. Out of 14 patients with stage IV disease, 8 patients received adjuvant chemotherapy and survived for 4.6 months whereas six patients who did not receive adjuvant chemotherapy survived for 1.3 months. This difference was statistically significant (p = 0.04). CONCLUSION: The majority of patients with gallbladder cancer presented with advanced stage disease (stage IV) which carries a dismal prognosis. Patients who received chemotherapy with stage IV disease, however, did better than those who did not, but this is probably a reflection of patient selection. BioMed Central 2005-03-17 /pmc/articles/PMC1079924/ /pubmed/15774016 http://dx.doi.org/10.1186/1477-7800-2-6 Text en Copyright © 2005 Memon et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Memon, Muhammed Ashraf
Anwar, Suhail
Shiwani, M Hanif
Memon, Breda
Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title_full Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title_fullStr Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title_full_unstemmed Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title_short Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
title_sort gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079924/
https://www.ncbi.nlm.nih.gov/pubmed/15774016
http://dx.doi.org/10.1186/1477-7800-2-6
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