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Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts

BACKGROUND: Anogenital warts are the most easily recognized sign of genital Human Papilloma Virus infection. The objective was to develop a short, valid and reliable questionnaire to measure Health Related Quality of Life (HRQL) in patients with anogenital warts. METHODS: First a literature review w...

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Autores principales: Badia, Xavier, Colombo, Jose Antonio, Lara, Nuria, Llorens, M Angels, Olmos, Luis, de los Terreros, Miguel Sainz, Varela, Jose Antonio, Vilata, Juan Jose
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087499/
https://www.ncbi.nlm.nih.gov/pubmed/15817127
http://dx.doi.org/10.1186/1477-7525-3-24
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author Badia, Xavier
Colombo, Jose Antonio
Lara, Nuria
Llorens, M Angels
Olmos, Luis
de los Terreros, Miguel Sainz
Varela, Jose Antonio
Vilata, Juan Jose
author_facet Badia, Xavier
Colombo, Jose Antonio
Lara, Nuria
Llorens, M Angels
Olmos, Luis
de los Terreros, Miguel Sainz
Varela, Jose Antonio
Vilata, Juan Jose
author_sort Badia, Xavier
collection PubMed
description BACKGROUND: Anogenital warts are the most easily recognized sign of genital Human Papilloma Virus infection. The objective was to develop a short, valid and reliable questionnaire to measure Health Related Quality of Life (HRQL) in patients with anogenital warts. METHODS: First a literature review was performed to identify relevant papers describing the impact of anogenital warts in HRQL; second the main domains were identified by some experts in a focus group, and third in-depth-semi-structured interviews were conducted in patients with anogenital warts to identify the initial set of items. A qualitative reduction of the initial set of items was performed based on the mean scoring of the experts for the three scales: clarity, frequency and importance. The initial questionnaire was pilot tested in 135 patients. Rasch analysis was performed with the results of the questionnaire in order to refine the instrument. Spearman's correlation was calculated between the initial questionnaire and the reduced version. Additionally the measurement properties (validity and reliability) of the resulting final questionnaire were tested and compared using standard procedures (Cronbach's Alpha and item-total correlation). RESULTS: the main domains identified as affected in patient's life were: sexual, colleagues and partner relationships. After a proper qualitative reduction the initial set of 134 items was reduced to 22. The questionnaire was pilot tested in 135 patients and two dimensions were identified after the multifactorial analysis: emotional dimension and sexual activity dimension. As a result of the Rasch analysis the questionnaire was reduced to 10 items. High correlation was found between the initial and the reduced version for the two dimensions. Cronbach's alpha values were acceptable (0.86). CONCLUSION: The initial 22 items questionnaire was reduced by Rasch analysis to a version of 10 items, with two dimensions: emotional and sexual. The results suggest the adequacy of the 10 items to evaluate HRQL of patients with anogenital warts in a valid and reliable way.
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spelling pubmed-10874992005-04-28 Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts Badia, Xavier Colombo, Jose Antonio Lara, Nuria Llorens, M Angels Olmos, Luis de los Terreros, Miguel Sainz Varela, Jose Antonio Vilata, Juan Jose Health Qual Life Outcomes Research BACKGROUND: Anogenital warts are the most easily recognized sign of genital Human Papilloma Virus infection. The objective was to develop a short, valid and reliable questionnaire to measure Health Related Quality of Life (HRQL) in patients with anogenital warts. METHODS: First a literature review was performed to identify relevant papers describing the impact of anogenital warts in HRQL; second the main domains were identified by some experts in a focus group, and third in-depth-semi-structured interviews were conducted in patients with anogenital warts to identify the initial set of items. A qualitative reduction of the initial set of items was performed based on the mean scoring of the experts for the three scales: clarity, frequency and importance. The initial questionnaire was pilot tested in 135 patients. Rasch analysis was performed with the results of the questionnaire in order to refine the instrument. Spearman's correlation was calculated between the initial questionnaire and the reduced version. Additionally the measurement properties (validity and reliability) of the resulting final questionnaire were tested and compared using standard procedures (Cronbach's Alpha and item-total correlation). RESULTS: the main domains identified as affected in patient's life were: sexual, colleagues and partner relationships. After a proper qualitative reduction the initial set of 134 items was reduced to 22. The questionnaire was pilot tested in 135 patients and two dimensions were identified after the multifactorial analysis: emotional dimension and sexual activity dimension. As a result of the Rasch analysis the questionnaire was reduced to 10 items. High correlation was found between the initial and the reduced version for the two dimensions. Cronbach's alpha values were acceptable (0.86). CONCLUSION: The initial 22 items questionnaire was reduced by Rasch analysis to a version of 10 items, with two dimensions: emotional and sexual. The results suggest the adequacy of the 10 items to evaluate HRQL of patients with anogenital warts in a valid and reliable way. BioMed Central 2005-04-07 /pmc/articles/PMC1087499/ /pubmed/15817127 http://dx.doi.org/10.1186/1477-7525-3-24 Text en Copyright © 2005 Badia et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Badia, Xavier
Colombo, Jose Antonio
Lara, Nuria
Llorens, M Angels
Olmos, Luis
de los Terreros, Miguel Sainz
Varela, Jose Antonio
Vilata, Juan Jose
Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title_full Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title_fullStr Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title_full_unstemmed Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title_short Combination of qualitative and quantitative methods for developing a new Health Related Quality of Life measure for patients with anogenital warts
title_sort combination of qualitative and quantitative methods for developing a new health related quality of life measure for patients with anogenital warts
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087499/
https://www.ncbi.nlm.nih.gov/pubmed/15817127
http://dx.doi.org/10.1186/1477-7525-3-24
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