Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen

Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55(gag )precursor into the mature p24 capsid immediately fol...

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Autores principales: Baird, Heather A, Marozsan, Andre J, Lederman, Michael M, Landay, Alan, Mildvan, Donna, Kuritzkes, Daniel R, Kessler, Harold A, Arts, Eric J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087826/
https://www.ncbi.nlm.nih.gov/pubmed/15826302
http://dx.doi.org/10.1186/1742-6405-2-2
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author Baird, Heather A
Marozsan, Andre J
Lederman, Michael M
Landay, Alan
Mildvan, Donna
Kuritzkes, Daniel R
Kessler, Harold A
Arts, Eric J
author_facet Baird, Heather A
Marozsan, Andre J
Lederman, Michael M
Landay, Alan
Mildvan, Donna
Kuritzkes, Daniel R
Kessler, Harold A
Arts, Eric J
author_sort Baird, Heather A
collection PubMed
description Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55(gag )precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.
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spelling pubmed-10878262005-04-30 Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen Baird, Heather A Marozsan, Andre J Lederman, Michael M Landay, Alan Mildvan, Donna Kuritzkes, Daniel R Kessler, Harold A Arts, Eric J AIDS Res Ther Research Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55(gag )precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks. BioMed Central 2005-04-12 /pmc/articles/PMC1087826/ /pubmed/15826302 http://dx.doi.org/10.1186/1742-6405-2-2 Text en Copyright © 2005 Baird et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Baird, Heather A
Marozsan, Andre J
Lederman, Michael M
Landay, Alan
Mildvan, Donna
Kuritzkes, Daniel R
Kessler, Harold A
Arts, Eric J
Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title_full Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title_fullStr Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title_full_unstemmed Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title_short Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
title_sort monitoring processed, mature human immunodeficiency virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087826/
https://www.ncbi.nlm.nih.gov/pubmed/15826302
http://dx.doi.org/10.1186/1742-6405-2-2
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