Cargando…

Oxygenation Inhibits the Physiological Tissue-Protecting Mechanism and Thereby Exacerbates Acute Inflammatory Lung Injury

Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use of high oxygen concentrations. Although oxygen therapy represents a life-saving measure, the recent discovery of a critical tissue-protecting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thiel, Manfred, Chouker, Alexander, Ohta, Akio, Jackson, Edward, Caldwell, Charles, Smith, Patrick, Lukashev, Dmitry, Bittmann, Iris, Sitkovsky, Michail V
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088279/ https://www.ncbi.nlm.nih.gov/pubmed/15857155 http://dx.doi.org/10.1371/journal.pbio.0030174

Ejemplares similares

From ‘Hellstrom Paradox–to anti-adenosinergic cancer immunotherapy
por: Lukashev, Dmitriy, et al.
Publicado: (2007)

Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival
por: Thiel, Manfred, et al.
Publicado: (2007)

In vivo T Cell Activation in Lymphoid Tissues is Inhibited in the Oxygen-Poor Microenvironment
por: Ohta, Akio, et al.
Publicado: (2011)

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells
por: Ohta, Akio, et al.
Publicado: (2014)

The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
por: Ohta, Akio, et al.
Publicado: (2012)

Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
por: Hatfield, Stephen M, et al.
Publicado: (2015)

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells
por: Sethumadhavan, Shalini, et al.
Publicado: (2017)

SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum
por: Liu, Rui, et al.
Publicado: (2018)

Epoetin beta pegol alleviates oxidative stress and exacerbation of renal damage from iron deposition, thereby delaying CKD progression in progressive glomerulonephritis rats
por: Hirata, Michinori, et al.
Publicado: (2015)

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats
por: Vlassaks, Evi, et al.
Publicado: (2013)

Dysferlin-Peptides Reallocate Mutated Dysferlin Thereby Restoring Function
por: Schoewel, Verena, et al.
Publicado: (2012)

Pectolinarin Inhibits the Bacterial Biofilm Formation and Thereby Reduces Bacterial Pathogenicity
por: Kim, Daseul, et al.
Publicado: (2022)

JAK3 Inhibition Regulates Stemness and Thereby Controls Glioblastoma Pathogenesis
por: Smedley, William, et al.
Publicado: (2023)

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection
por: Honda-Okubo, Yoshikazu, et al.
Publicado: (2015)

Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis
por: Wu, Tong, et al.
Publicado: (2023)

CO(2) exacerbates oxygen toxicity
por: Ezraty, Benjamin, et al.
Publicado: (2011)

Cell Wall Composition Impacts Structural Characteristics of the Stems and Thereby the Biomass Yield
por: Ana, López-Malvar, et al.
Publicado: (2022)

The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity
por: Huang, Xinfang, et al.
Publicado: (2021)

Cell Wall Composition Impacts Structural Characteristics of the Stems and Thereby Biomass Yield
por: López-Malvar, Ana, et al.
Publicado: (2022)

Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding
por: Peters, Christian, et al.
Publicado: (2023)

Exhaled Breath and Oxygenator Sweep Gas Propionaldehyde in Acute Respiratory Distress Syndrome
por: Meidert, Agnes S., et al.
Publicado: (2020)

Behavior of oxygen saturation and blood filling in the venous capillary system of the biceps brachii muscle during a fatiguing isometric action
por: Dech, Silas, et al.
Publicado: (2020)

Mechanotendography: description and evaluation of a novel method for investigating the physiological mechanical oscillations of tendons using a piezo-based measurement system
por: Schaefer, Laura V., et al.
Publicado: (2021)

Motion Sickness, Stress and the Endocannabinoid System
por: Choukèr, Alexander, et al.
Publicado: (2010)

Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance
por: Imperatrice, Maria, et al.
Publicado: (2022)

Ultraprotective versus apneic ventilation in acute respiratory distress syndrome patients with extracorporeal membrane oxygenation: a physiological study
por: Graf, Peter T., et al.
Publicado: (2022)

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation
por: Ueda, Koji, et al.
Publicado: (2019)

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
por: Carriba, P, et al.
Publicado: (2015)

The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
por: Mages, Kristin, et al.
Publicado: (2019)

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
por: Stouffer, Melissa A., et al.
Publicado: (2015)

Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth
por: Lee, Soo-Yeon, et al.
Publicado: (2018)

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance
por: Kale, Justin, et al.
Publicado: (2018)

Schistocephalus parasite infection alters sticklebacks’ movement ability and thereby shapes social interactions
por: Jolles, Jolle W., et al.
Publicado: (2020)

Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation
por: Schnitzler, Johan G., et al.
Publicado: (2020)

Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia
por: Correale, Pierpaolo, et al.
Publicado: (2020)

Muscle Oxygenation Level Might Trigger the Regulation of Capillary Venous Blood Filling during Fatiguing Isometric Muscle Actions
por: Dech, Silas, et al.
Publicado: (2021)

Muscle oxygenation and time to task failure of submaximal holding and pulling isometric muscle actions and influence of intermittent voluntary muscle twitches
por: Dech, Silas, et al.
Publicado: (2022)

Physiological Effects of Oxygen
Publicado: (1873)

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness
por: Koh, Jaemoon, et al.
Publicado: (2023)

Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice
por: Mizokami, Akiko, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vbeh3jbt1epkbhqnfbtum9vdnv