Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation

Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function. The mechanism of initiator caspase activation has been generalized by the induced proximity model, which is thought to drive dimeriz...

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Detalles Bibliográficos
Autores principales: Chao, Yang, Shiozaki, Eric N, Srinivasula, Srinivasa M, Rigotti, Daniel J, Fairman, Robert, Shi, Yigong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088972/
https://www.ncbi.nlm.nih.gov/pubmed/15941357
http://dx.doi.org/10.1371/journal.pbio.0030183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088972/
https://www.ncbi.nlm.nih.gov/pubmed/15941357
http://dx.doi.org/10.1371/journal.pbio.0030183

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