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Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation
Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function. The mechanism of initiator caspase activation has been generalized by the induced proximity model, which is thought to drive dimeriz...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088972/ https://www.ncbi.nlm.nih.gov/pubmed/15941357 http://dx.doi.org/10.1371/journal.pbio.0030183 |