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Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states

In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on...

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Autores principales: Garoflos, Efstathios, Panagiotaropoulos, Theofanis, Pondiki, Stavroula, Stamatakis, Antonios, Philippidis, Eleni, Stylianopoulou, Fotini
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090442/
https://www.ncbi.nlm.nih.gov/pubmed/15876359
http://dx.doi.org/10.1186/1744-859X-4-8
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author Garoflos, Efstathios
Panagiotaropoulos, Theofanis
Pondiki, Stavroula
Stamatakis, Antonios
Philippidis, Eleni
Stylianopoulou, Fotini
author_facet Garoflos, Efstathios
Panagiotaropoulos, Theofanis
Pondiki, Stavroula
Stamatakis, Antonios
Philippidis, Eleni
Stylianopoulou, Fotini
author_sort Garoflos, Efstathios
collection PubMed
description In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on circulating leptin levels, of male rats. METHOD: Spatial learning and memory following an acute restraint stress (30 min) were assessed in the Morris water maze. Hippocampal GR, MR and BDNF levels were determined immunocytochemically. 5-HT1A receptors were quantified by in vitro binding autoradiography. Circulating leptin levels, following a chronic forced swimming stress, were measured by radioimmunoassay (RIA). Data were statistically analyzed by analysis of variance (ANOVA). RESULTS: Neonatal handling increased the ability of male rats for spatial learning and memory. It also resulted in increased GR/MR ratio, BDNF and 5-HT1A receptor levels in the hippocampus. Furthermore, leptin levels, body weight and food consumption during chronic forced swimming stress were reduced as a result of handling. CONCLUSION: Neonatal handling is shown to have a beneficial effect in the males, improving their cognitive abilities. This effect on behavior could be mediated by the handling-induced increase in hippocampal GR/MR ratio and BDNF levels. The handling-induced changes in BDNF and 5-HT1A receptors could underlie the previously documented effect of handling in preventing "depression". Furthermore, handling is shown to prevent other maladaptive states such as stress-induced hyperphagia, obesity and resistance to leptin.
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spelling pubmed-10904422005-05-06 Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states Garoflos, Efstathios Panagiotaropoulos, Theofanis Pondiki, Stavroula Stamatakis, Antonios Philippidis, Eleni Stylianopoulou, Fotini Ann Gen Psychiatry Primary Research In the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (GR), mineralocorticoid (MR) and type 1A serotonin (5-HT1A) receptors, as well as brain derived neurotrophic factor (BDNF), and on circulating leptin levels, of male rats. METHOD: Spatial learning and memory following an acute restraint stress (30 min) were assessed in the Morris water maze. Hippocampal GR, MR and BDNF levels were determined immunocytochemically. 5-HT1A receptors were quantified by in vitro binding autoradiography. Circulating leptin levels, following a chronic forced swimming stress, were measured by radioimmunoassay (RIA). Data were statistically analyzed by analysis of variance (ANOVA). RESULTS: Neonatal handling increased the ability of male rats for spatial learning and memory. It also resulted in increased GR/MR ratio, BDNF and 5-HT1A receptor levels in the hippocampus. Furthermore, leptin levels, body weight and food consumption during chronic forced swimming stress were reduced as a result of handling. CONCLUSION: Neonatal handling is shown to have a beneficial effect in the males, improving their cognitive abilities. This effect on behavior could be mediated by the handling-induced increase in hippocampal GR/MR ratio and BDNF levels. The handling-induced changes in BDNF and 5-HT1A receptors could underlie the previously documented effect of handling in preventing "depression". Furthermore, handling is shown to prevent other maladaptive states such as stress-induced hyperphagia, obesity and resistance to leptin. BioMed Central 2005-04-06 /pmc/articles/PMC1090442/ /pubmed/15876359 http://dx.doi.org/10.1186/1744-859X-4-8 Text en Copyright © 2005 Garoflos et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Primary Research
Garoflos, Efstathios
Panagiotaropoulos, Theofanis
Pondiki, Stavroula
Stamatakis, Antonios
Philippidis, Eleni
Stylianopoulou, Fotini
Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title_full Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title_fullStr Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title_full_unstemmed Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title_short Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
title_sort cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090442/
https://www.ncbi.nlm.nih.gov/pubmed/15876359
http://dx.doi.org/10.1186/1744-859X-4-8
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