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Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
BACKGROUND: We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant p53. Since the expression of WAF1 is up-regulated by activated wildtype p53, glycerol appears to restore wtp53 function. The aim of the...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111188/ https://www.ncbi.nlm.nih.gov/pubmed/11965244 http://dx.doi.org/10.1186/1472-6750-2-6 |