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Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse
BACKGROUND: The serotonergic system is associated with numerous brain functions, including the resetting of the mammalian circadian clock. The synthesis and metabolism of 5-HT in the brain increases in response to exercise and is correlated with high levels of blood-borne tryptophan (TRP). The prese...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112610/ https://www.ncbi.nlm.nih.gov/pubmed/15860131 http://dx.doi.org/10.1186/1740-3391-3-6 |
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author | Piccione, Giuseppe Assenza, Anna Fazio, Francesco Percipalle, Maurizio Caola, Giovanni |
author_facet | Piccione, Giuseppe Assenza, Anna Fazio, Francesco Percipalle, Maurizio Caola, Giovanni |
author_sort | Piccione, Giuseppe |
collection | PubMed |
description | BACKGROUND: The serotonergic system is associated with numerous brain functions, including the resetting of the mammalian circadian clock. The synthesis and metabolism of 5-HT in the brain increases in response to exercise and is correlated with high levels of blood-borne tryptophan (TRP). The present investigation was aimed at testing the existence of a daily rhythm of TRP and 5-HT in the blood of athletic horses. METHODS: Blood samples from 5 Thoroughbred mares were collected at 4-hour intervals for 48 hours (starting at 08:00 hours on day 1 and finishing at 4:00 on day 2) via an intravenous cannula inserted into the jugular vein. Tryptophan and serotonin concentrations were assessed by HPLC. Data analysis was conducted by one-way repeated measures analysis of variance (ANOVA) and by the single cosinor method. RESULTS: ANOVA showed a highly significant influence of time both on tryptophan and on serotonin, in all horses, on either day, with p values < 0.0001. Cosinor analysis identified the periodic parameters and their acrophases (expressed in hours) during the 2 days of monitoring. Both parameters studied showed evening acrophases. CONCLUSION: The results showed that serotonin and tryptophan blood levels undergo nycthemeral variation with typical evening acrophases. These results enhance the understanding of the athlete horse's chronoperformance and facilitate the establishment of training programs that take into account the nycthemeral pattern of aminoacids deeply involved in the onset of central fatigue. |
format | Text |
id | pubmed-1112610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11126102005-05-14 Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse Piccione, Giuseppe Assenza, Anna Fazio, Francesco Percipalle, Maurizio Caola, Giovanni J Circadian Rhythms Short Paper BACKGROUND: The serotonergic system is associated with numerous brain functions, including the resetting of the mammalian circadian clock. The synthesis and metabolism of 5-HT in the brain increases in response to exercise and is correlated with high levels of blood-borne tryptophan (TRP). The present investigation was aimed at testing the existence of a daily rhythm of TRP and 5-HT in the blood of athletic horses. METHODS: Blood samples from 5 Thoroughbred mares were collected at 4-hour intervals for 48 hours (starting at 08:00 hours on day 1 and finishing at 4:00 on day 2) via an intravenous cannula inserted into the jugular vein. Tryptophan and serotonin concentrations were assessed by HPLC. Data analysis was conducted by one-way repeated measures analysis of variance (ANOVA) and by the single cosinor method. RESULTS: ANOVA showed a highly significant influence of time both on tryptophan and on serotonin, in all horses, on either day, with p values < 0.0001. Cosinor analysis identified the periodic parameters and their acrophases (expressed in hours) during the 2 days of monitoring. Both parameters studied showed evening acrophases. CONCLUSION: The results showed that serotonin and tryptophan blood levels undergo nycthemeral variation with typical evening acrophases. These results enhance the understanding of the athlete horse's chronoperformance and facilitate the establishment of training programs that take into account the nycthemeral pattern of aminoacids deeply involved in the onset of central fatigue. BioMed Central 2005-04-28 /pmc/articles/PMC1112610/ /pubmed/15860131 http://dx.doi.org/10.1186/1740-3391-3-6 Text en Copyright © 2005 Piccione et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Paper Piccione, Giuseppe Assenza, Anna Fazio, Francesco Percipalle, Maurizio Caola, Giovanni Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title | Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title_full | Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title_fullStr | Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title_full_unstemmed | Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title_short | Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
title_sort | central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse |
topic | Short Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112610/ https://www.ncbi.nlm.nih.gov/pubmed/15860131 http://dx.doi.org/10.1186/1740-3391-3-6 |
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