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Anti-inflammatory therapy by ibudilast, a phosphodiesterase inhibitor, in demyelination of twitcher, a genetic demyelination model
BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112612/ https://www.ncbi.nlm.nih.gov/pubmed/15813970 http://dx.doi.org/10.1186/1742-2094-2-10 |