Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

We report the first in vitro and genetic confirmation of Malarone(®) (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a mal...

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Autores principales: Fivelman, Quinton L, Butcher, Geoffrey A, Adagu, Ipemida S, Warhurst, David C, Pasvol, Geoffrey
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111499/
https://www.ncbi.nlm.nih.gov/pubmed/12057021
http://dx.doi.org/10.1186/1475-2875-1-1
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author Fivelman, Quinton L
Butcher, Geoffrey A
Adagu, Ipemida S
Warhurst, David C
Pasvol, Geoffrey
author_facet Fivelman, Quinton L
Butcher, Geoffrey A
Adagu, Ipemida S
Warhurst, David C
Pasvol, Geoffrey
author_sort Fivelman, Quinton L
collection PubMed
description We report the first in vitro and genetic confirmation of Malarone(®) (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone(®). Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.
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spelling pubmed-1114992002-05-20 Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria Fivelman, Quinton L Butcher, Geoffrey A Adagu, Ipemida S Warhurst, David C Pasvol, Geoffrey Malar J Case Report We report the first in vitro and genetic confirmation of Malarone(®) (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone(®). Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously. BioMed Central 2002-02-08 /pmc/articles/PMC111499/ /pubmed/12057021 http://dx.doi.org/10.1186/1475-2875-1-1 Text en Copyright © 2002 Fivelman et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Case Report
Fivelman, Quinton L
Butcher, Geoffrey A
Adagu, Ipemida S
Warhurst, David C
Pasvol, Geoffrey
Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title_full Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title_fullStr Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title_full_unstemmed Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title_short Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
title_sort malarone treatment failure and in vitro confirmation of resistance of plasmodium falciparum isolate from lagos, nigeria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111499/
https://www.ncbi.nlm.nih.gov/pubmed/12057021
http://dx.doi.org/10.1186/1475-2875-1-1
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