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Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia

BACKGROUND: T cells play a dominant role in the pathogenesis of asthma. Costimulation of T cells is necessary to fully activate them. An inducible costimulator (ICOS) of T cells is predominantly expressed on Th2 cells. Therefore, interference of signaling pathways precipitated by ICOS may present ne...

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Detalles Bibliográficos
Autores principales:	Chialda, Ligia, Zhang, Meixia, Brune, Kay, Pahl, Andreas
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131927/ https://www.ncbi.nlm.nih.gov/pubmed/15833106 http://dx.doi.org/10.1186/1465-9921-6-36

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