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Four base recognition by triplex-forming oligonucleotides at physiological pH

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2′-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine] recognizes AT base pairs with high affinity, (Me)P (3-methyl-2 aminopyr...

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Detalles Bibliográficos
Autores principales:	Rusling, David A., Powers, Vicki E. C., Ranasinghe, Rohan T., Wang, Yang, Osborne, Sadie D., Brown, Tom, Fox, Keith R.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137030/ https://www.ncbi.nlm.nih.gov/pubmed/15911633 http://dx.doi.org/10.1093/nar/gki625

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