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Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

microRNAs (miRNAs) are single-stranded, 21- to 23-nucleotide cellular RNAs that control the expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed to mature miRNA by the successive actions of two RNase III endonucleases. Drosha converts pri-miRNA transcripts to pre...

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Detalles Bibliográficos
Autores principales:	Förstemann, Klaus, Tomari, Yukihide, Du, Tingting, Vagin, Vasily V, Denli, Ahmet M, Bratu, Diana P, Klattenhoff, Carla, Theurkauf, William E, Zamore, Phillip D
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1141267/ https://www.ncbi.nlm.nih.gov/pubmed/15918770 http://dx.doi.org/10.1371/journal.pbio.0030236

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