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Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice
In the present paper we review a series of experiments showing that heritable variations in the size of the hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields correlate with performance in spatial, but not non-spatial radial-maze tasks. Experimental manipulation of the size of...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143776/ https://www.ncbi.nlm.nih.gov/pubmed/15916698 http://dx.doi.org/10.1186/1744-9081-1-3 |
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author | Crusio, Wim E Schwegler, Herbert |
author_facet | Crusio, Wim E Schwegler, Herbert |
author_sort | Crusio, Wim E |
collection | PubMed |
description | In the present paper we review a series of experiments showing that heritable variations in the size of the hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields correlate with performance in spatial, but not non-spatial radial-maze tasks. Experimental manipulation of the size of this projection by means of early postnatal hyperthyroidism produces the effects predicted from the correlations obtained with inbred mouse strains. Although the physiological mechanisms behind these correlations are unknown as yet, several lines of evidence indicate that these correlations are causal. |
format | Text |
id | pubmed-1143776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11437762005-06-09 Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice Crusio, Wim E Schwegler, Herbert Behav Brain Funct Review In the present paper we review a series of experiments showing that heritable variations in the size of the hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields correlate with performance in spatial, but not non-spatial radial-maze tasks. Experimental manipulation of the size of this projection by means of early postnatal hyperthyroidism produces the effects predicted from the correlations obtained with inbred mouse strains. Although the physiological mechanisms behind these correlations are unknown as yet, several lines of evidence indicate that these correlations are causal. BioMed Central 2005-04-22 /pmc/articles/PMC1143776/ /pubmed/15916698 http://dx.doi.org/10.1186/1744-9081-1-3 Text en Copyright © 2005 Crusio and Schwegler; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Crusio, Wim E Schwegler, Herbert Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title | Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title_full | Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title_fullStr | Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title_full_unstemmed | Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title_short | Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
title_sort | learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143776/ https://www.ncbi.nlm.nih.gov/pubmed/15916698 http://dx.doi.org/10.1186/1744-9081-1-3 |
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