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Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients

BACKGROUND: Previous preliminary reports have suggested potential interactions between microcytic anaemia and mood disorders. In particular, heterozygous β-thalassaemia has been implicated in the bipolar spectrum. This study surveyed relevant haematological parameters in a large sample of psychiatri...

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Autor principal: Bocchetta, Alberto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156923/
https://www.ncbi.nlm.nih.gov/pubmed/15967056
http://dx.doi.org/10.1186/1745-0179-1-6
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author Bocchetta, Alberto
author_facet Bocchetta, Alberto
author_sort Bocchetta, Alberto
collection PubMed
description BACKGROUND: Previous preliminary reports have suggested potential interactions between microcytic anaemia and mood disorders. In particular, heterozygous β-thalassaemia has been implicated in the bipolar spectrum. This study surveyed relevant haematological parameters in a large sample of psychiatric outpatients with the aim of clarifying previous observations. METHODS: Mean Corpuscular Volume (MCV) was analysed in 1014 consecutive patients diagnosed according to modified Research Diagnostic Criteria (RDC). Haemoglobin electrophoresis and/or chromatography was performed in blood samples from 143 patients with reduced MCV. Prevalence of heterozygous β-thalassaemia was estimated based on the rates of patients with reduced MCV and increased haemoglobin A(2 )concentration. RESULTS: MCV lower than 80 μ(3 )was found in greater proportions among bipolar compared with the remaining RDC subgroups (183/732 = 25.0% versus 51/282 = 18.1%; p = 0.02; relative risk = 1.38; Fisher's exact test). This difference can mainly be attributed to heterozygous β-thalassaemia, the estimated prevalence of which was 16.4% among bipolar and 9.9% among non-bipolar subgroups (p = 0.01; relative risk = 1.65). CONCLUSION: The results are consistent with the hypothesis that heterozygous β-thalassaemia might play a role as a susceptibility factor in bipolar spectrum disorders in specific populations.
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spelling pubmed-11569232005-06-22 Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients Bocchetta, Alberto Clin Pract Epidemiol Ment Health Research BACKGROUND: Previous preliminary reports have suggested potential interactions between microcytic anaemia and mood disorders. In particular, heterozygous β-thalassaemia has been implicated in the bipolar spectrum. This study surveyed relevant haematological parameters in a large sample of psychiatric outpatients with the aim of clarifying previous observations. METHODS: Mean Corpuscular Volume (MCV) was analysed in 1014 consecutive patients diagnosed according to modified Research Diagnostic Criteria (RDC). Haemoglobin electrophoresis and/or chromatography was performed in blood samples from 143 patients with reduced MCV. Prevalence of heterozygous β-thalassaemia was estimated based on the rates of patients with reduced MCV and increased haemoglobin A(2 )concentration. RESULTS: MCV lower than 80 μ(3 )was found in greater proportions among bipolar compared with the remaining RDC subgroups (183/732 = 25.0% versus 51/282 = 18.1%; p = 0.02; relative risk = 1.38; Fisher's exact test). This difference can mainly be attributed to heterozygous β-thalassaemia, the estimated prevalence of which was 16.4% among bipolar and 9.9% among non-bipolar subgroups (p = 0.01; relative risk = 1.65). CONCLUSION: The results are consistent with the hypothesis that heterozygous β-thalassaemia might play a role as a susceptibility factor in bipolar spectrum disorders in specific populations. BioMed Central 2005-06-01 /pmc/articles/PMC1156923/ /pubmed/15967056 http://dx.doi.org/10.1186/1745-0179-1-6 Text en Copyright ©2005 Bocchetta; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bocchetta, Alberto
Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title_full Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title_fullStr Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title_full_unstemmed Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title_short Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
title_sort heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156923/
https://www.ncbi.nlm.nih.gov/pubmed/15967056
http://dx.doi.org/10.1186/1745-0179-1-6
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