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Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs

A CpG-containing DNA oligonucleotide functionalized with the 2-(N-formyl-N-methyl)aminoethyl thiophosphate protecting group (CpG ODN fma1555) was prepared from phosphoramidites 1a–d using solid-phase techniques. The oligonucleotide behaved as a prodrug by virtue of its conversion to the well-studied...

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Detalles Bibliográficos
Autores principales:	Grajkowski, Andrzej, Pedras-Vasconcelos, Joao, Wang, Vivian, Ausín, Cristina, Hess, Sonja, Verthelyi, Daniela, Beaucage, Serge L.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156963/ https://www.ncbi.nlm.nih.gov/pubmed/15972797 http://dx.doi.org/10.1093/nar/gki657

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