Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

BACKGROUND: Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival. Reintroduction of PTEN in cells suppresses transformation and tumorigenicity....

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Detalles Bibliográficos
Autores principales: Seely, B Lynn, Samimi, Goli, Webster, Nicholas JG
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115841/
https://www.ncbi.nlm.nih.gov/pubmed/12057025
http://dx.doi.org/10.1186/1471-2407-2-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115841/
https://www.ncbi.nlm.nih.gov/pubmed/12057025
http://dx.doi.org/10.1186/1471-2407-2-15

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