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RNALOSS: a web server for RNA locally optimal secondary structures
RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it i...
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160143/ https://www.ncbi.nlm.nih.gov/pubmed/15980545 http://dx.doi.org/10.1093/nar/gki382 |
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author | Clote, P. |
author_facet | Clote, P. |
author_sort | Clote, P. |
collection | PubMed |
description | RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it is important to gain insight into the folding process of RNA sequences. We describe the web server RNALOSS, which provides information about the distribution of locally optimal secondary structures, that possibly form kinetic traps in the folding process. The tool RNALOSS may be useful in designing RNA sequences which not only have low folding energy, but whose distribution of locally optimal secondary structures would suggest rapid and robust folding. Website: . |
format | Text |
id | pubmed-1160143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-11601432005-06-29 RNALOSS: a web server for RNA locally optimal secondary structures Clote, P. Nucleic Acids Res Article RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it is important to gain insight into the folding process of RNA sequences. We describe the web server RNALOSS, which provides information about the distribution of locally optimal secondary structures, that possibly form kinetic traps in the folding process. The tool RNALOSS may be useful in designing RNA sequences which not only have low folding energy, but whose distribution of locally optimal secondary structures would suggest rapid and robust folding. Website: . Oxford University Press 2005-07-01 2005-06-27 /pmc/articles/PMC1160143/ /pubmed/15980545 http://dx.doi.org/10.1093/nar/gki382 Text en © The Author 2005. Published by Oxford University Press. All rights reserved |
spellingShingle | Article Clote, P. RNALOSS: a web server for RNA locally optimal secondary structures |
title | RNALOSS: a web server for RNA locally optimal secondary structures |
title_full | RNALOSS: a web server for RNA locally optimal secondary structures |
title_fullStr | RNALOSS: a web server for RNA locally optimal secondary structures |
title_full_unstemmed | RNALOSS: a web server for RNA locally optimal secondary structures |
title_short | RNALOSS: a web server for RNA locally optimal secondary structures |
title_sort | rnaloss: a web server for rna locally optimal secondary structures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160143/ https://www.ncbi.nlm.nih.gov/pubmed/15980545 http://dx.doi.org/10.1093/nar/gki382 |
work_keys_str_mv | AT clotep rnalossawebserverforrnalocallyoptimalsecondarystructures |