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RNALOSS: a web server for RNA locally optimal secondary structures

RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it i...

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Detalles Bibliográficos
Autor principal: Clote, P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160143/
https://www.ncbi.nlm.nih.gov/pubmed/15980545
http://dx.doi.org/10.1093/nar/gki382
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author Clote, P.
author_facet Clote, P.
author_sort Clote, P.
collection PubMed
description RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it is important to gain insight into the folding process of RNA sequences. We describe the web server RNALOSS, which provides information about the distribution of locally optimal secondary structures, that possibly form kinetic traps in the folding process. The tool RNALOSS may be useful in designing RNA sequences which not only have low folding energy, but whose distribution of locally optimal secondary structures would suggest rapid and robust folding. Website: .
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spelling pubmed-11601432005-06-29 RNALOSS: a web server for RNA locally optimal secondary structures Clote, P. Nucleic Acids Res Article RNAomics, analogous to proteomics, concerns aspects of the secondary and tertiary structure, folding pathway, kinetics, comparison, function and regulation of all RNA in a living organism. Given recently discovered roles played by micro RNA, small interfering RNA, riboswitches, ribozymes, etc., it is important to gain insight into the folding process of RNA sequences. We describe the web server RNALOSS, which provides information about the distribution of locally optimal secondary structures, that possibly form kinetic traps in the folding process. The tool RNALOSS may be useful in designing RNA sequences which not only have low folding energy, but whose distribution of locally optimal secondary structures would suggest rapid and robust folding. Website: . Oxford University Press 2005-07-01 2005-06-27 /pmc/articles/PMC1160143/ /pubmed/15980545 http://dx.doi.org/10.1093/nar/gki382 Text en © The Author 2005. Published by Oxford University Press. All rights reserved
spellingShingle Article
Clote, P.
RNALOSS: a web server for RNA locally optimal secondary structures
title RNALOSS: a web server for RNA locally optimal secondary structures
title_full RNALOSS: a web server for RNA locally optimal secondary structures
title_fullStr RNALOSS: a web server for RNA locally optimal secondary structures
title_full_unstemmed RNALOSS: a web server for RNA locally optimal secondary structures
title_short RNALOSS: a web server for RNA locally optimal secondary structures
title_sort rnaloss: a web server for rna locally optimal secondary structures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160143/
https://www.ncbi.nlm.nih.gov/pubmed/15980545
http://dx.doi.org/10.1093/nar/gki382
work_keys_str_mv AT clotep rnalossawebserverforrnalocallyoptimalsecondarystructures