Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC

Comparative analysis of genomic sequences is a powerful approach to discover functional sites in these sequences. Herein, we present a WWW-based software system for multiple alignment of genomic sequences. We use the local alignment tool CHAOS to rapidly identify chains of pairwise similarities. The...

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Detalles Bibliográficos
Autores principales: Pöhler, Dirk, Werner, Nadine, Steinkamp, Rasmus, Morgenstern, Burkhard
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160147/
https://www.ncbi.nlm.nih.gov/pubmed/15980528
http://dx.doi.org/10.1093/nar/gki386
Descripción
Sumario:Comparative analysis of genomic sequences is a powerful approach to discover functional sites in these sequences. Herein, we present a WWW-based software system for multiple alignment of genomic sequences. We use the local alignment tool CHAOS to rapidly identify chains of pairwise similarities. These similarities are used as anchor points to speed up the DIALIGN multiple-alignment program. Finally, the visualization tool ABC is used for interactive graphical representation of the resulting multiple alignments. Our software is available at Göttingen Bioinformatics Compute Server (GOBICS) at

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