Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC

Comparative analysis of genomic sequences is a powerful approach to discover functional sites in these sequences. Herein, we present a WWW-based software system for multiple alignment of genomic sequences. We use the local alignment tool CHAOS to rapidly identify chains of pairwise similarities. The...

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Detalles Bibliográficos
Autores principales: Pöhler, Dirk, Werner, Nadine, Steinkamp, Rasmus, Morgenstern, Burkhard
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160147/
https://www.ncbi.nlm.nih.gov/pubmed/15980528
http://dx.doi.org/10.1093/nar/gki386
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author Pöhler, Dirk
Werner, Nadine
Steinkamp, Rasmus
Morgenstern, Burkhard
author_facet Pöhler, Dirk
Werner, Nadine
Steinkamp, Rasmus
Morgenstern, Burkhard
author_sort Pöhler, Dirk
collection PubMed
description Comparative analysis of genomic sequences is a powerful approach to discover functional sites in these sequences. Herein, we present a WWW-based software system for multiple alignment of genomic sequences. We use the local alignment tool CHAOS to rapidly identify chains of pairwise similarities. These similarities are used as anchor points to speed up the DIALIGN multiple-alignment program. Finally, the visualization tool ABC is used for interactive graphical representation of the resulting multiple alignments. Our software is available at Göttingen Bioinformatics Compute Server (GOBICS) at
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spelling pubmed-11601472005-06-29 Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC Pöhler, Dirk Werner, Nadine Steinkamp, Rasmus Morgenstern, Burkhard Nucleic Acids Res Article Comparative analysis of genomic sequences is a powerful approach to discover functional sites in these sequences. Herein, we present a WWW-based software system for multiple alignment of genomic sequences. We use the local alignment tool CHAOS to rapidly identify chains of pairwise similarities. These similarities are used as anchor points to speed up the DIALIGN multiple-alignment program. Finally, the visualization tool ABC is used for interactive graphical representation of the resulting multiple alignments. Our software is available at Göttingen Bioinformatics Compute Server (GOBICS) at Oxford University Press 2005-07-01 2005-06-27 /pmc/articles/PMC1160147/ /pubmed/15980528 http://dx.doi.org/10.1093/nar/gki386 Text en © The Author 2005. Published by Oxford University Press. All rights reserved
spellingShingle Article
Pöhler, Dirk
Werner, Nadine
Steinkamp, Rasmus
Morgenstern, Burkhard
Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title_full Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title_fullStr Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title_full_unstemmed Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title_short Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
title_sort multiple alignment of genomic sequences using chaos, dialign and abc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160147/
https://www.ncbi.nlm.nih.gov/pubmed/15980528
http://dx.doi.org/10.1093/nar/gki386
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