Cargando…

KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites

KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are lea...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Hsien-Da, Lee, Tzong-Yi, Tzeng, Shih-Wei, Horng, Jorng-Tzong
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160232/
https://www.ncbi.nlm.nih.gov/pubmed/15980458
http://dx.doi.org/10.1093/nar/gki471
_version_ 1782124386912829440
author Huang, Hsien-Da
Lee, Tzong-Yi
Tzeng, Shih-Wei
Horng, Jorng-Tzong
author_facet Huang, Hsien-Da
Lee, Tzong-Yi
Tzeng, Shih-Wei
Horng, Jorng-Tzong
author_sort Huang, Hsien-Da
collection PubMed
description KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at .
format Text
id pubmed-1160232
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-11602322005-06-29 KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites Huang, Hsien-Da Lee, Tzong-Yi Tzeng, Shih-Wei Horng, Jorng-Tzong Nucleic Acids Res Article KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at . Oxford University Press 2005-07-01 2005-06-27 /pmc/articles/PMC1160232/ /pubmed/15980458 http://dx.doi.org/10.1093/nar/gki471 Text en © The Author 2005. Published by Oxford University Press. All rights reserved
spellingShingle Article
Huang, Hsien-Da
Lee, Tzong-Yi
Tzeng, Shih-Wei
Horng, Jorng-Tzong
KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title_full KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title_fullStr KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title_full_unstemmed KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title_short KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
title_sort kinasephos: a web tool for identifying protein kinase-specific phosphorylation sites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160232/
https://www.ncbi.nlm.nih.gov/pubmed/15980458
http://dx.doi.org/10.1093/nar/gki471
work_keys_str_mv AT huanghsienda kinasephosawebtoolforidentifyingproteinkinasespecificphosphorylationsites
AT leetzongyi kinasephosawebtoolforidentifyingproteinkinasespecificphosphorylationsites
AT tzengshihwei kinasephosawebtoolforidentifyingproteinkinasespecificphosphorylationsites
AT horngjorngtzong kinasephosawebtoolforidentifyingproteinkinasespecificphosphorylationsites