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KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are lea...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160232/ https://www.ncbi.nlm.nih.gov/pubmed/15980458 http://dx.doi.org/10.1093/nar/gki471 |
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author | Huang, Hsien-Da Lee, Tzong-Yi Tzeng, Shih-Wei Horng, Jorng-Tzong |
author_facet | Huang, Hsien-Da Lee, Tzong-Yi Tzeng, Shih-Wei Horng, Jorng-Tzong |
author_sort | Huang, Hsien-Da |
collection | PubMed |
description | KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at . |
format | Text |
id | pubmed-1160232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-11602322005-06-29 KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites Huang, Hsien-Da Lee, Tzong-Yi Tzeng, Shih-Wei Horng, Jorng-Tzong Nucleic Acids Res Article KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at . Oxford University Press 2005-07-01 2005-06-27 /pmc/articles/PMC1160232/ /pubmed/15980458 http://dx.doi.org/10.1093/nar/gki471 Text en © The Author 2005. Published by Oxford University Press. All rights reserved |
spellingShingle | Article Huang, Hsien-Da Lee, Tzong-Yi Tzeng, Shih-Wei Horng, Jorng-Tzong KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title | KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title_full | KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title_fullStr | KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title_full_unstemmed | KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title_short | KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites |
title_sort | kinasephos: a web tool for identifying protein kinase-specific phosphorylation sites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160232/ https://www.ncbi.nlm.nih.gov/pubmed/15980458 http://dx.doi.org/10.1093/nar/gki471 |
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