Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats

BACKGROUND: The p16(INK4A) gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme, contributing to unchecked Rb phosphorylation and rapid cell division. We show here that transduction of the human p16...

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Detalles Bibliográficos
Autores principales: Strauss, Bryan E, Fontes, Ricardo BV, Lotfi, Claudimara FP, Skorupa, Ana Lucia, Bartol, Ione, Cipolla-Neto, José, Costanzi-Strauss, Eugenia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116432/
https://www.ncbi.nlm.nih.gov/pubmed/11983028
http://dx.doi.org/10.1186/1475-2867-2-2

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