Cargando…
TRIM5α selectively binds a restriction-sensitive retroviral capsid
TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for re...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166576/ https://www.ncbi.nlm.nih.gov/pubmed/15967037 http://dx.doi.org/10.1186/1742-4690-2-40 |
_version_ | 1782124432152592384 |
---|---|
author | Sebastian, Sarah Luban, Jeremy |
author_facet | Sebastian, Sarah Luban, Jeremy |
author_sort | Sebastian, Sarah |
collection | PubMed |
description | TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction. |
format | Text |
id | pubmed-1166576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11665762005-06-30 TRIM5α selectively binds a restriction-sensitive retroviral capsid Sebastian, Sarah Luban, Jeremy Retrovirology Short Report TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction. BioMed Central 2005-06-20 /pmc/articles/PMC1166576/ /pubmed/15967037 http://dx.doi.org/10.1186/1742-4690-2-40 Text en Copyright © 2005 Sebastian and Luban; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Sebastian, Sarah Luban, Jeremy TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title_full | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title_fullStr | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title_full_unstemmed | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title_short | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
title_sort | trim5α selectively binds a restriction-sensitive retroviral capsid |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166576/ https://www.ncbi.nlm.nih.gov/pubmed/15967037 http://dx.doi.org/10.1186/1742-4690-2-40 |
work_keys_str_mv | AT sebastiansarah trim5aselectivelybindsarestrictionsensitiveretroviralcapsid AT lubanjeremy trim5aselectivelybindsarestrictionsensitiveretroviralcapsid |