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Functional group interactions of a 5-HT(3)R antagonist

BACKGROUND: Lerisetron, a competitive serotonin type 3 receptor (5-HT(3)R) antagonist, contains five functional groups capable of interacting with amino acids in the 5-HT(3)R binding site. Site directed mutagenesis studies of the 5-HT(3A)R have revealed several amino acids that are thought to form p...

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Detalles Bibliográficos
Autores principales:	Venkataraman, Padmavati, Joshi, Prasad, Venkatachalan, Srinivasan P, Muthalagi, Mani, Parihar, Harish S, Kirschbaum, Karen S, Schulte, Marvin K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2002
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116678/ https://www.ncbi.nlm.nih.gov/pubmed/12079499 http://dx.doi.org/10.1186/1471-2091-3-16

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