CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis

Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with an...

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Autores principales: Martin, AC, Laing, IA, Zhang, G, Brennan, S, Winfield, K, Sly, PD, Stick, SM, Goldblatt, J, LeSouef, PN
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168907/
https://www.ncbi.nlm.nih.gov/pubmed/15975149
http://dx.doi.org/10.1186/1465-9921-6-63
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author Martin, AC
Laing, IA
Zhang, G
Brennan, S
Winfield, K
Sly, PD
Stick, SM
Goldblatt, J
LeSouef, PN
author_facet Martin, AC
Laing, IA
Zhang, G
Brennan, S
Winfield, K
Sly, PD
Stick, SM
Goldblatt, J
LeSouef, PN
author_sort Martin, AC
collection PubMed
description Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma sCD14 levels were significantly lower in children from whom P.aeruginosa was subsequently isolated (492.75 μg/ml vs. 1339.43 μg/ml, p = 0.018). Those with the CD14 -159CC genotype had a significantly increased risk of early infection with P.aeruginosa suggesting that CD14 C-159T plays a role in determining the risk of early infection with P.aeruginosa.
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spelling pubmed-11689072005-07-02 CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis Martin, AC Laing, IA Zhang, G Brennan, S Winfield, K Sly, PD Stick, SM Goldblatt, J LeSouef, PN Respir Res Research Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients with cystic fibrosis. We investigated whether polymorphisms in CD14, the lipopolysaccharide receptor, increase the risk of early infection. Forty-five children with cystic fibrosis were investigated with annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma sCD14 levels were significantly lower in children from whom P.aeruginosa was subsequently isolated (492.75 μg/ml vs. 1339.43 μg/ml, p = 0.018). Those with the CD14 -159CC genotype had a significantly increased risk of early infection with P.aeruginosa suggesting that CD14 C-159T plays a role in determining the risk of early infection with P.aeruginosa. BioMed Central 2005 2005-06-23 /pmc/articles/PMC1168907/ /pubmed/15975149 http://dx.doi.org/10.1186/1465-9921-6-63 Text en Copyright © 2005 Martin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Martin, AC
Laing, IA
Zhang, G
Brennan, S
Winfield, K
Sly, PD
Stick, SM
Goldblatt, J
LeSouef, PN
CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title_full CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title_fullStr CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title_full_unstemmed CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title_short CD14 C-159T and early infection with Pseudomonas aeruginosa in children with cystic fibrosis
title_sort cd14 c-159t and early infection with pseudomonas aeruginosa in children with cystic fibrosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168907/
https://www.ncbi.nlm.nih.gov/pubmed/15975149
http://dx.doi.org/10.1186/1465-9921-6-63
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