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Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands
Mutations in mammalian and Drosophila Hel308 and PolQ paralogues cause genome instability but their helicase functions are mysterious. By in vivo and in vitro analysis, we show that Hel308 from archaea (Hel308a) may act at stalled replication forks. Introducing hel308a into Escherichia coli dnaE str...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168952/ https://www.ncbi.nlm.nih.gov/pubmed/15994460 http://dx.doi.org/10.1093/nar/gki685 |