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Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study

BACKGROUND: Very low birthweight, i.e. a birthweight < 1500 g, is among the strongest determinants of infant mortality and childhood morbidity. To develop primary prevention approaches to VLBW birth and its sequelae, information is needed on the causes of preterm birth, their personal and social...

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Autores principales: Grimmer, Ingrid, Bührer, Christoph, Dudenhausen, Joachim W, Stroux, Andrea, Reiher, Horst, Halle, Horst, Obladen, Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117217/
https://www.ncbi.nlm.nih.gov/pubmed/12095425
http://dx.doi.org/10.1186/1471-2458-2-10
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author Grimmer, Ingrid
Bührer, Christoph
Dudenhausen, Joachim W
Stroux, Andrea
Reiher, Horst
Halle, Horst
Obladen, Michael
author_facet Grimmer, Ingrid
Bührer, Christoph
Dudenhausen, Joachim W
Stroux, Andrea
Reiher, Horst
Halle, Horst
Obladen, Michael
author_sort Grimmer, Ingrid
collection PubMed
description BACKGROUND: Very low birthweight, i.e. a birthweight < 1500 g, is among the strongest determinants of infant mortality and childhood morbidity. To develop primary prevention approaches to VLBW birth and its sequelae, information is needed on the causes of preterm birth, their personal and social antecedents, and on conditions associated with very low birthweight. Despite the growing body of evidence linking sociodemographic variables with preterm delivery, little is known as to how this may be extrapolated to the risk of very low birthweight. METHODS: In 1992, two years after the German unification, we started to recruit two cohorts of very low birthweight infants and controls in East and West Berlin for a long-term neurodevelopmental study. The present analysis was undertaken to compare potential preconceptional risk factors for very low birthweight delivery in a case-control design including 166 mothers (82 East vs. 84 West Berlin) with very low birthweight delivery and 341 control mothers (166 East vs. 175 West). RESULTS: Multivariate logistic regression analysis was used to assess the effects of various dichotomous parental covariates and their interaction with living in East or West Berlin. After backward variable selection, short maternal school education, maternal unemployment, single-room apartment, smoking, previous preterm delivery, and fetal loss emerged as significant main effect variables, together with living in West Berlin as positive effect modificator for single-mother status. CONCLUSION: Very low birthweight has been differentially associated with obstetrical history and indicators of maternal socioeconomic status in East and West Berlin. The ranking of these risk factors is under the influence of the political framework.
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spelling pubmed-1172172002-07-18 Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study Grimmer, Ingrid Bührer, Christoph Dudenhausen, Joachim W Stroux, Andrea Reiher, Horst Halle, Horst Obladen, Michael BMC Public Health Research Article BACKGROUND: Very low birthweight, i.e. a birthweight < 1500 g, is among the strongest determinants of infant mortality and childhood morbidity. To develop primary prevention approaches to VLBW birth and its sequelae, information is needed on the causes of preterm birth, their personal and social antecedents, and on conditions associated with very low birthweight. Despite the growing body of evidence linking sociodemographic variables with preterm delivery, little is known as to how this may be extrapolated to the risk of very low birthweight. METHODS: In 1992, two years after the German unification, we started to recruit two cohorts of very low birthweight infants and controls in East and West Berlin for a long-term neurodevelopmental study. The present analysis was undertaken to compare potential preconceptional risk factors for very low birthweight delivery in a case-control design including 166 mothers (82 East vs. 84 West Berlin) with very low birthweight delivery and 341 control mothers (166 East vs. 175 West). RESULTS: Multivariate logistic regression analysis was used to assess the effects of various dichotomous parental covariates and their interaction with living in East or West Berlin. After backward variable selection, short maternal school education, maternal unemployment, single-room apartment, smoking, previous preterm delivery, and fetal loss emerged as significant main effect variables, together with living in West Berlin as positive effect modificator for single-mother status. CONCLUSION: Very low birthweight has been differentially associated with obstetrical history and indicators of maternal socioeconomic status in East and West Berlin. The ranking of these risk factors is under the influence of the political framework. BioMed Central 2002-06-24 /pmc/articles/PMC117217/ /pubmed/12095425 http://dx.doi.org/10.1186/1471-2458-2-10 Text en Copyright © 2002 Grimmer et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Grimmer, Ingrid
Bührer, Christoph
Dudenhausen, Joachim W
Stroux, Andrea
Reiher, Horst
Halle, Horst
Obladen, Michael
Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title_full Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title_fullStr Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title_full_unstemmed Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title_short Preconceptional factors associated with very low birthweight delivery in East and West Berlin: a case control study
title_sort preconceptional factors associated with very low birthweight delivery in east and west berlin: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117217/
https://www.ncbi.nlm.nih.gov/pubmed/12095425
http://dx.doi.org/10.1186/1471-2458-2-10
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