Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H(2 )to PGE(2). Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthr...

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Detalles Bibliográficos
Autores principales: Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174970/
https://www.ncbi.nlm.nih.gov/pubmed/15899061
http://dx.doi.org/10.1186/ar1748
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author Sampey, Annaleise V
Monrad, Seetha
Crofford, Leslie J
author_facet Sampey, Annaleise V
Monrad, Seetha
Crofford, Leslie J
author_sort Sampey, Annaleise V
collection PubMed
description Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H(2 )to PGE(2). Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE(2 )observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.
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spelling pubmed-11749702005-07-13 Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2) Sampey, Annaleise V Monrad, Seetha Crofford, Leslie J Arthritis Res Ther Commentary Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H(2 )to PGE(2). Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE(2 )observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis. BioMed Central 2005 2005-04-06 /pmc/articles/PMC1174970/ /pubmed/15899061 http://dx.doi.org/10.1186/ar1748 Text en Copyright © 2005 BioMed Central Ltd
spellingShingle Commentary
Sampey, Annaleise V
Monrad, Seetha
Crofford, Leslie J
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title_full Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title_fullStr Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title_full_unstemmed Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title_short Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)
title_sort microsomal prostaglandin e synthase-1: the inducible synthase for prostaglandin e(2)
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174970/
https://www.ncbi.nlm.nih.gov/pubmed/15899061
http://dx.doi.org/10.1186/ar1748
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AT monradseetha microsomalprostaglandinesynthase1theinduciblesynthaseforprostaglandine2
AT croffordlesliej microsomalprostaglandinesynthase1theinduciblesynthaseforprostaglandine2

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