Cargando…

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E(2)

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H(2 )to PGE(2). Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174970/ https://www.ncbi.nlm.nih.gov/pubmed/15899061 http://dx.doi.org/10.1186/ar1748

Ejemplares similares

Upregulation of prostaglandin E(2) by inducible microsomal prostaglandin E synthase-1 in colon cancer
por: Kim, Young Hun, et al.
Publicado: (2022)

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
por: Zhou, Jiping, et al.
Publicado: (2012)

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases
por: Korotkova, Marina, et al.
Publicado: (2011)

Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E(2) synthesis in vitro and ameliorates experimental periodontitis in vivo
por: Kats, Anna, et al.
Publicado: (2013)

Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes
por: Afif, H, et al.
Publicado: (2004)

Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Pulmonary Fibrosis Induced by Bleomycin in Mice
por: Wei, Bo, et al.
Publicado: (2014)

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1
por: Cao, Long-Long, et al.
Publicado: (2019)

Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice
por: Gurusamy, Malarvizhi, et al.
Publicado: (2021)

An Update of Microsomal Prostaglandin E Synthase-1 and PGE(2) Receptors in Cardiovascular Health and Diseases
por: Yang, Guangrui, et al.
Publicado: (2016)

Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies
por: Korotkova, M, et al.
Publicado: (2005)

Pharmacological Characterization of the Microsomal Prostaglandin E(2) Synthase-1 Inhibitor AF3485 In Vitro and In Vivo
por: Di Francesco, Luigia, et al.
Publicado: (2020)

Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease
por: Kotsos, Dimitrios, et al.
Publicado: (2023)

Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E(2) synthase up-regulation for colorectal cancer progression
por: Stamatakis, Konstantinos, et al.
Publicado: (2015)

Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes
por: Zayed, N, et al.
Publicado: (2010)

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
por: Korotkova, M, et al.
Publicado: (2004)

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo
por: Koeberle, Andreas, et al.
Publicado: (2011)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
por: Kock, Anna, et al.
Publicado: (2018)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia
por: Mukai, Manabu, et al.
Publicado: (2018)

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
por: Kamei, Daisuke, et al.
Publicado: (2009)

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
por: Yasmen, Nelufar, et al.
Publicado: (2023)

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E(2) Synthase 1 and Ser127 Is Not
por: Raouf, Joan, et al.
Publicado: (2016)

Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1
por: Sasaki, Yuka, et al.
Publicado: (2015)

Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
por: Pierre, Clément, et al.
Publicado: (2018)

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis
por: Korotkova, M, et al.
Publicado: (2008)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E(2) accumulation in labor
por: Takahashi, Nanase, et al.
Publicado: (2021)

Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice
por: Nakanishi, Masako, et al.
Publicado: (2021)

Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1
por: Tuure, Lauri, et al.
Publicado: (2017)

An Insect Prostaglandin E(2) Synthase Acts in Immunity and Reproduction
por: Ahmed, Shabbir, et al.
Publicado: (2018)

Prostaglandin E(2 )is an enhancer for IL-1β-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts
por: Kojima, F, et al.
Publicado: (2003)

The role of mPGES-1 for prostaglandin E(2 )production in primary human synovial cells
por: Crofford, L, et al.
Publicado: (2003)

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE(2) Production in Bone Marrow Derived Macrophages
por: Xiao, Lei, et al.
Publicado: (2012)

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis
por: Finetti, Federica, et al.
Publicado: (2012)

Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction
por: Lin, You-Min, et al.
Publicado: (2018)

Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E(2) Synthase-1
por: Verhoff, Moritz, et al.
Publicado: (2014)

Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model
por: Henkel, Janin, et al.
Publicado: (2018)

Regulation of microsomal prostaglandin E(2 )synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
por: Chen, Shu-Huang, et al.
Publicado: (2010)

PDE4 inhibitor rolipram inhibits the expression of microsomal prostaglandin E synthase‐1 by a mechanism dependent on MAP kinase phosphatase‐1
por: Tuure, Lauri, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pbc2mmpof5pb2ki1t2dbpietf9