NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis

In previous studies we have found that FcγRI determines chondrocyte death and matrix metalloproteinase (MMP)-mediated cartilage destruction during IFN-γ-regulated immune complex arthritis (ICA). Binding of immune complexes (ICs) to FcγRI leads to the prominent production of oxygen radicals. In the p...

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Detalles Bibliográficos
Autores principales: van Lent, Peter LEM, Nabbe, Karin CAM, Blom, Arjen B, Sloetjes, Annet, Holthuysen, Astrid EM, Kolls, Jay, Van De Loo, Fons AJ, Holland, Steven M, Van Den Berg, Wim B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175041/
https://www.ncbi.nlm.nih.gov/pubmed/15987491
http://dx.doi.org/10.1186/ar1760

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