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CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells

BACKGROUND: The hCMV promoter is very commonly used for high level expression of transgenes in mammalian cells, but its utility is hindered by transcriptional silencing. Large genomic fragments incorporating the CpG island region of the HNRPA2B1 locus are resistant to transcriptional silencing. RESU...

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Detalles Bibliográficos
Autores principales:	Williams, Steven, Mustoe, Tracey, Mulcahy, Tony, Griffiths, Mark, Simpson, David, Antoniou, Michael, Irvine, Alistair, Mountain, Andrew, Crombie, Robert
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175082/ https://www.ncbi.nlm.nih.gov/pubmed/15935093 http://dx.doi.org/10.1186/1472-6750-5-17

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