Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C

INTRODUCTION: Studies in vitro reveal that endothelin-1 (ET-1) activates the α isoform of protein kinase C (PKC-α) in cultures of endothelial cells, thereby deranging cellular integrity. Sepsis and endotoxemia are associated with increased plasma concentrations of ET-1 that induce acute lung injury...

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Detalles Bibliográficos
Autores principales: Kuklin, Vladimir, Kirov, Mikhail, Sovershaev, Mikhail, Andreasen, Thomas, Ingebretsen, Ole C, Ytrehus, Kirsti, Bjertnaes, Lars
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175881/
https://www.ncbi.nlm.nih.gov/pubmed/15987392
http://dx.doi.org/10.1186/cc3497

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