Cargando…
Uneven distribution of ventilation in acute respiratory distress syndrome
INTRODUCTION: The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS: A prospective, descriptive study was performed of 25...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175934/ https://www.ncbi.nlm.nih.gov/pubmed/15774050 http://dx.doi.org/10.1186/cc3058 |
_version_ | 1782124543593152512 |
---|---|
author | Rylander, Christian Tylén, Ulf Rossi-Norrlund, Rauni Herrmann, Peter Quintel, Michael Bake, Björn |
author_facet | Rylander, Christian Tylén, Ulf Rossi-Norrlund, Rauni Herrmann, Peter Quintel, Michael Bake, Björn |
author_sort | Rylander, Christian |
collection | PubMed |
description | INTRODUCTION: The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS: A prospective, descriptive study was performed of 25 sedated and paralysed ARDS patients, mechanically ventilated with a positive end-expiratory pressure (PEEP) of 5 cmH(2)O in a multidisciplinary intensive care unit of a tertiary university hospital. The volume of poorly ventilated or non-ventilated gas was assumed to correspond to a difference between the ventilated gas volume, determined as the end-expiratory lung volume by rebreathing of sulphur hexafluoride (EELV(SF6)), and the total gas volume, calculated from computed tomography images in the end-expiratory position (EELV(CT)). The methods used were validated by similar measurements in 20 healthy subjects in whom no poorly ventilated or non-ventilated gas is expected to be found. RESULTS: EELV(SF6 )was 66% of EELV(CT), corresponding to a mean difference of 0.71 litre. EELV(SF6 )and EELV(CT )were significantly correlated (r(2 )= 0.72; P < 0.001). In the healthy subjects, the two methods yielded almost identical results. CONCLUSION: About one-third of the total pulmonary gas volume seems poorly ventilated or non-ventilated in sedated and paralysed ARDS patients when mechanically ventilated with a PEEP of 5 cmH(2)O. Uneven distribution of ventilation due to airway closure and/or obstruction is likely to be involved. |
format | Text |
id | pubmed-1175934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11759342005-07-17 Uneven distribution of ventilation in acute respiratory distress syndrome Rylander, Christian Tylén, Ulf Rossi-Norrlund, Rauni Herrmann, Peter Quintel, Michael Bake, Björn Crit Care Research INTRODUCTION: The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS: A prospective, descriptive study was performed of 25 sedated and paralysed ARDS patients, mechanically ventilated with a positive end-expiratory pressure (PEEP) of 5 cmH(2)O in a multidisciplinary intensive care unit of a tertiary university hospital. The volume of poorly ventilated or non-ventilated gas was assumed to correspond to a difference between the ventilated gas volume, determined as the end-expiratory lung volume by rebreathing of sulphur hexafluoride (EELV(SF6)), and the total gas volume, calculated from computed tomography images in the end-expiratory position (EELV(CT)). The methods used were validated by similar measurements in 20 healthy subjects in whom no poorly ventilated or non-ventilated gas is expected to be found. RESULTS: EELV(SF6 )was 66% of EELV(CT), corresponding to a mean difference of 0.71 litre. EELV(SF6 )and EELV(CT )were significantly correlated (r(2 )= 0.72; P < 0.001). In the healthy subjects, the two methods yielded almost identical results. CONCLUSION: About one-third of the total pulmonary gas volume seems poorly ventilated or non-ventilated in sedated and paralysed ARDS patients when mechanically ventilated with a PEEP of 5 cmH(2)O. Uneven distribution of ventilation due to airway closure and/or obstruction is likely to be involved. BioMed Central 2005 2005-02-21 /pmc/articles/PMC1175934/ /pubmed/15774050 http://dx.doi.org/10.1186/cc3058 Text en Copyright © 2005 Rylander et al.; licensee BioMed Central Ltd. |
spellingShingle | Research Rylander, Christian Tylén, Ulf Rossi-Norrlund, Rauni Herrmann, Peter Quintel, Michael Bake, Björn Uneven distribution of ventilation in acute respiratory distress syndrome |
title | Uneven distribution of ventilation in acute respiratory distress syndrome |
title_full | Uneven distribution of ventilation in acute respiratory distress syndrome |
title_fullStr | Uneven distribution of ventilation in acute respiratory distress syndrome |
title_full_unstemmed | Uneven distribution of ventilation in acute respiratory distress syndrome |
title_short | Uneven distribution of ventilation in acute respiratory distress syndrome |
title_sort | uneven distribution of ventilation in acute respiratory distress syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175934/ https://www.ncbi.nlm.nih.gov/pubmed/15774050 http://dx.doi.org/10.1186/cc3058 |
work_keys_str_mv | AT rylanderchristian unevendistributionofventilationinacuterespiratorydistresssyndrome AT tylenulf unevendistributionofventilationinacuterespiratorydistresssyndrome AT rossinorrlundrauni unevendistributionofventilationinacuterespiratorydistresssyndrome AT herrmannpeter unevendistributionofventilationinacuterespiratorydistresssyndrome AT quintelmichael unevendistributionofventilationinacuterespiratorydistresssyndrome AT bakebjorn unevendistributionofventilationinacuterespiratorydistresssyndrome |