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Histone modifications: from genome-wide maps to functional insights
A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175962/ https://www.ncbi.nlm.nih.gov/pubmed/15960810 http://dx.doi.org/10.1186/gb-2005-6-6-113 |
| _version_ | 1782124550839861248 |
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| author | van Leeuwen, Fred van Steensel, Bas |
| author_facet | van Leeuwen, Fred van Steensel, Bas |
| author_sort | van Leeuwen, Fred |
| collection | PubMed |
| description | A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward. |
| format | Text |
| id | pubmed-1175962 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2005 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-11759622005-07-17 Histone modifications: from genome-wide maps to functional insights van Leeuwen, Fred van Steensel, Bas Genome Biol Opinion A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward. BioMed Central 2005 2005-05-31 /pmc/articles/PMC1175962/ /pubmed/15960810 http://dx.doi.org/10.1186/gb-2005-6-6-113 Text en Copyright © 2005 BioMed Central Ltd |
| spellingShingle | Opinion van Leeuwen, Fred van Steensel, Bas Histone modifications: from genome-wide maps to functional insights |
| title | Histone modifications: from genome-wide maps to functional insights |
| title_full | Histone modifications: from genome-wide maps to functional insights |
| title_fullStr | Histone modifications: from genome-wide maps to functional insights |
| title_full_unstemmed | Histone modifications: from genome-wide maps to functional insights |
| title_short | Histone modifications: from genome-wide maps to functional insights |
| title_sort | histone modifications: from genome-wide maps to functional insights |
| topic | Opinion |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175962/ https://www.ncbi.nlm.nih.gov/pubmed/15960810 http://dx.doi.org/10.1186/gb-2005-6-6-113 |
| work_keys_str_mv | AT vanleeuwenfred histonemodificationsfromgenomewidemapstofunctionalinsights AT vansteenselbas histonemodificationsfromgenomewidemapstofunctionalinsights |