Conservation anchors in the vertebrate genome

Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with thei...

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Detalles Bibliográficos
Autores principales: Aloni, Ronny, Lancet, Doron
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175977/
https://www.ncbi.nlm.nih.gov/pubmed/15998454
http://dx.doi.org/10.1186/gb-2005-6-7-115
Descripción
Sumario:Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with their (correlated) inter-species identity scores, helps in assessing the probability that they function in transcription regulation or RNA coding.

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