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Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins
BACKGROUND: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein's evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyleti...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175987/ https://www.ncbi.nlm.nih.gov/pubmed/15998445 http://dx.doi.org/10.1186/gb-2005-6-7-r56 |
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author | Freilich, Shiri Massingham, Tim Bhattacharyya, Sumit Ponstingl, Hannes Lyons, Paul A Freeman, Tom C Thornton, Janet M |
author_facet | Freilich, Shiri Massingham, Tim Bhattacharyya, Sumit Ponstingl, Hannes Lyons, Paul A Freeman, Tom C Thornton, Janet M |
author_sort | Freilich, Shiri |
collection | PubMed |
description | BACKGROUND: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein's evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. RESULTS: Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast, the tissue-specific set is dominated by regulatory proteins (signal transduction and transcription factors). An increased tendency to tissue-specificity is observed for metazoan-specific proteins. As the composition of the phyletic groups highly correlates with that of the functional groups, the data were tested in order to determine which of the two factors - function or phyletic age - is dominant in shaping the expression profile of a protein. The observed differences in expression patterns of genes between functional groups were found mainly to reflect their different phyletic origin. The connection between tissue specificity and phyletic age cannot be explained by the recent rate of evolution. Finally, although metazoan-specific proteins tend to be tissue-specific compared with phyletically conserved proteins present in all domains of life, many such 'universal' proteins are also tissue-specific. CONCLUSION: The minimal cellular transcriptome of the metazoan cell differs from that of the ancestral unicellular eukaryote: new functions were added (metazoan-specific proteins), whilst other functions became specialized and no longer took place in all cells (tissue-specific pre-metazoan proteins). |
format | Text |
id | pubmed-1175987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11759872005-07-17 Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins Freilich, Shiri Massingham, Tim Bhattacharyya, Sumit Ponstingl, Hannes Lyons, Paul A Freeman, Tom C Thornton, Janet M Genome Biol Research BACKGROUND: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein's evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. RESULTS: Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast, the tissue-specific set is dominated by regulatory proteins (signal transduction and transcription factors). An increased tendency to tissue-specificity is observed for metazoan-specific proteins. As the composition of the phyletic groups highly correlates with that of the functional groups, the data were tested in order to determine which of the two factors - function or phyletic age - is dominant in shaping the expression profile of a protein. The observed differences in expression patterns of genes between functional groups were found mainly to reflect their different phyletic origin. The connection between tissue specificity and phyletic age cannot be explained by the recent rate of evolution. Finally, although metazoan-specific proteins tend to be tissue-specific compared with phyletically conserved proteins present in all domains of life, many such 'universal' proteins are also tissue-specific. CONCLUSION: The minimal cellular transcriptome of the metazoan cell differs from that of the ancestral unicellular eukaryote: new functions were added (metazoan-specific proteins), whilst other functions became specialized and no longer took place in all cells (tissue-specific pre-metazoan proteins). BioMed Central 2005 2005-06-29 /pmc/articles/PMC1175987/ /pubmed/15998445 http://dx.doi.org/10.1186/gb-2005-6-7-r56 Text en Copyright © 2005 Freilich et al.; licensee BioMed Central Ltd. |
spellingShingle | Research Freilich, Shiri Massingham, Tim Bhattacharyya, Sumit Ponstingl, Hannes Lyons, Paul A Freeman, Tom C Thornton, Janet M Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title | Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title_full | Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title_fullStr | Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title_full_unstemmed | Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title_short | Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
title_sort | relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175987/ https://www.ncbi.nlm.nih.gov/pubmed/15998445 http://dx.doi.org/10.1186/gb-2005-6-7-r56 |
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