Movement in ribosome translocation

Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G•GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-e...

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Detalles Bibliográficos
Autores principales: Fraser, Christopher S, Hershey, John WB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175999/
https://www.ncbi.nlm.nih.gov/pubmed/15985151
http://dx.doi.org/10.1186/jbiol27
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author Fraser, Christopher S
Hershey, John WB
author_facet Fraser, Christopher S
Hershey, John WB
author_sort Fraser, Christopher S
collection PubMed
description Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G•GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.
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spelling pubmed-11759992005-07-17 Movement in ribosome translocation Fraser, Christopher S Hershey, John WB J Biol Minireview Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G•GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation. BioMed Central 2005 2005-06-27 /pmc/articles/PMC1175999/ /pubmed/15985151 http://dx.doi.org/10.1186/jbiol27 Text en Copyright © 2005 BioMed Central Ltd
spellingShingle Minireview
Fraser, Christopher S
Hershey, John WB
Movement in ribosome translocation
title Movement in ribosome translocation
title_full Movement in ribosome translocation
title_fullStr Movement in ribosome translocation
title_full_unstemmed Movement in ribosome translocation
title_short Movement in ribosome translocation
title_sort movement in ribosome translocation
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175999/
https://www.ncbi.nlm.nih.gov/pubmed/15985151
http://dx.doi.org/10.1186/jbiol27
work_keys_str_mv AT fraserchristophers movementinribosometranslocation
AT hersheyjohnwb movementinribosometranslocation

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