Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from the Netherlands cohort study

BACKGROUND: Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a large population-based case group. METHODS: Cases were identified within the...

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Detalles Bibliográficos
Autores principales: van Houwelingen, Kjeld P, van Dijk, Boukje AC, Hulsbergen-van de Kaa, Christina A, Schouten, Leo J, Gorissen, Hanneke JM, Schalken, Jack A, van den Brandt, Piet A, Oosterwijk, Egbert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177929/
https://www.ncbi.nlm.nih.gov/pubmed/15932632
http://dx.doi.org/10.1186/1471-2407-5-57

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