Cargando…
The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003
BACKGROUND: The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177968/ https://www.ncbi.nlm.nih.gov/pubmed/15960856 http://dx.doi.org/10.1186/1471-2458-5-68 |
_version_ | 1782124580481007616 |
---|---|
author | Yih, W Katherine Brooks, Daniel R Lett, Susan M Jumaan, Aisha O Zhang, Zi Clements, Karen M Seward, Jane F |
author_facet | Yih, W Katherine Brooks, Daniel R Lett, Susan M Jumaan, Aisha O Zhang, Zi Clements, Karen M Seward, Jane F |
author_sort | Yih, W Katherine |
collection | PubMed |
description | BACKGROUND: The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus. METHODS: In 1998–2003, as varicella vaccine uptake increased, incidence of varicella and herpes zoster in Massachusetts was monitored using the random-digit-dial Behavioral Risk Factor Surveillance System. RESULTS: Between 1998 and 2003, varicella incidence declined from 16.5/1,000 to 3.5/1,000 (79%) overall with ≥66% decreases for all age groups except adults (27% decrease). Age-standardized estimates of overall herpes zoster occurrence increased from 2.77/1,000 to 5.25/1,000 (90%) in the period 1999–2003, and the trend in both crude and adjusted rates was highly significant (p < 0.001). Annual age-specific rates were somewhat unstable, but all increased, and the trend was significant for the 25–44 year and 65+ year age groups. CONCLUSION: As varicella vaccine coverage in children increased, the incidence of varicella decreased and the occurrence of herpes zoster increased. If the observed increase in herpes zoster incidence is real, widespread vaccination of children is only one of several possible explanations. Further studies are needed to understand secular trends in herpes zoster before and after use of varicella vaccine in the United States and other countries. |
format | Text |
id | pubmed-1177968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11779682005-07-21 The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 Yih, W Katherine Brooks, Daniel R Lett, Susan M Jumaan, Aisha O Zhang, Zi Clements, Karen M Seward, Jane F BMC Public Health Research Article BACKGROUND: The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus. METHODS: In 1998–2003, as varicella vaccine uptake increased, incidence of varicella and herpes zoster in Massachusetts was monitored using the random-digit-dial Behavioral Risk Factor Surveillance System. RESULTS: Between 1998 and 2003, varicella incidence declined from 16.5/1,000 to 3.5/1,000 (79%) overall with ≥66% decreases for all age groups except adults (27% decrease). Age-standardized estimates of overall herpes zoster occurrence increased from 2.77/1,000 to 5.25/1,000 (90%) in the period 1999–2003, and the trend in both crude and adjusted rates was highly significant (p < 0.001). Annual age-specific rates were somewhat unstable, but all increased, and the trend was significant for the 25–44 year and 65+ year age groups. CONCLUSION: As varicella vaccine coverage in children increased, the incidence of varicella decreased and the occurrence of herpes zoster increased. If the observed increase in herpes zoster incidence is real, widespread vaccination of children is only one of several possible explanations. Further studies are needed to understand secular trends in herpes zoster before and after use of varicella vaccine in the United States and other countries. BioMed Central 2005-06-16 /pmc/articles/PMC1177968/ /pubmed/15960856 http://dx.doi.org/10.1186/1471-2458-5-68 Text en Copyright © 2005 Yih et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yih, W Katherine Brooks, Daniel R Lett, Susan M Jumaan, Aisha O Zhang, Zi Clements, Karen M Seward, Jane F The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title | The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title_full | The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title_fullStr | The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title_full_unstemmed | The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title_short | The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003 |
title_sort | incidence of varicella and herpes zoster in massachusetts as measured by the behavioral risk factor surveillance system (brfss) during a period of increasing varicella vaccine coverage, 1998–2003 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177968/ https://www.ncbi.nlm.nih.gov/pubmed/15960856 http://dx.doi.org/10.1186/1471-2458-5-68 |
work_keys_str_mv | AT yihwkatherine theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT brooksdanielr theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT lettsusanm theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT jumaanaishao theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT zhangzi theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT clementskarenm theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT sewardjanef theincidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT yihwkatherine incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT brooksdanielr incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT lettsusanm incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT jumaanaishao incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT zhangzi incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT clementskarenm incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 AT sewardjanef incidenceofvaricellaandherpeszosterinmassachusettsasmeasuredbythebehavioralriskfactorsurveillancesystembrfssduringaperiodofincreasingvaricellavaccinecoverage19982003 |